Award Data

DESCRIPTION (provided by applicant): Addiction annually costs America gt 500B. Narcotic addiction is especially worrisome since intravenous drug abuse (IVDA) also promotes HIV transmission. Reducing IVDA is critical to lowering the incidence of HIV. Sincegt75% of IVDA is with opioids, effective treatment of opiate addiction should markedly reduce IVDA and lower HIV transmission rates. Naltrexone ...

DESCRIPTION (provided by applicant): The treatment of injuries or diseases affecting articular or elastic cartilage poses important unmet challenges to the medical community. The goal of this Phase I SBIR is to further the development of a method for themanufacture of a biologically-derived biomaterial that can maintain a pre-defined anatomical shape, while supporting the synthesis of a new tissu ...

DESCRIPTION (provided by applicant): Acute myocardial infarction is the leading cause of death in most industrialized nations. The estimated annual incidence in the US is 865,000 events, with ST-segment elevation myocardial infarction (STEMI, severe AMI)comprising an estimated 500,000 events per year. Fibrinolytic therapy is widely utilized to restore coronary blood flow due to its widespread ava ...

DESCRIPTION (provided by applicant): Current nurse call systems lack patient-centric interfaces (i.e. pillow speakers) and the ability to relay specific requests to the most appropriat providers, which negatively impacts operational efficiency. Further, existing systems neither provide a means for limited English proficiency (LEP) patients to make call requests in their native language nor the abi ...

DESCRIPTION (provided by applicant): Helminth infections are responsible for severe health problems worldwide, in both human and animal populations. It is estimated that 2-3 billion people, mainly from rural and impoverished regions of the world suffer from disease due to parasitic nematodes; however, drug development and discovery efforts lack commitment to combat human infection due to the poor ...

DESCRIPTION (provided by applicant): Glaucoma drainage devices (GDDs) have widely been used in the treatment of high-risk refractory glaucoma. To avoid tube exposure, which may lead to serious eye infection, the implanted GDD tube must be covered by apatch graft traditionally made of either donor sclera or pericardium. However, these patch grafts still carry a high rate of progressive thinning ...

A MODEL SYSTEM IS CREATED TO DETERMINE THE FEASIBILITY OF DEVELOPING INTEGRATED COMPUTER SOFTWARE FOR ANATOMIC PATHOLOGY MANAGEMENT INFORMATION. THE SOFTWARE COMBINES SEVERAL UNIQUE DIAGNOSTIC CODING FUNCTIONS, IS TRANSPORTABLE TO THE MAJOR COMPUTER ARCHITECTURES, AND IS EFFICIENT THE OBJECTIVES ARE TO: 1. INTEGRATE APPLICABLE PATIENT INFORMATION OBTAINED AUTOMATICALLY FROM HOSPITAL SOURCES DIRECT ...

AN ADVERSE REACTION TO A DRUG WHICH TAKES PLACE WHILE A PATIENT IS ON MEDICATION IS OFTEN IMPOSSIBLE TO DIAGNOSE ACCURATELY. THE NATURE OF THE UNDERLYING REACTION MAY HAVE AN IMMUNOLOGIC, TOXICOLOGIC, OR PHARMACOLOGIC BASIS. AMONG THE MOST NOTABLE IMMUNOLOGIC REACTIONS TO DRUGS ARE THOSE WHICH GIVE RISE TO ANTIBODIES THAT, IN THE PRESENCE OF DRUG, ATTACH TO BLOOD CELLS AND DESTROY THEM. THE MOST C ...

DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of antisense technologies to the study of human diseases has been proven in the literature for cancer, im ...

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