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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases

    SBC: Nanode Therapeutics, Inc.            Topic: NCATS

    STTR_Developing Nanopieces 7. Project Summary/Abstract The bottleneck of developing new RNAi (RNA Interference) drugs is the lack of highly efficient and non-toxic RNA delivery to non-liver tissues in vivo. It is especially challenging to deliver negatively-charged nucleic acid into avascular, dense, and negatively-charged matrix in hard-to-reach tissues including joint cartilage. NanoDe Therapeut ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Caduceus Quest: An interactive digital media resource to promote knowledge of reproductive health and STEM

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: 500

    PROJECT ABSTRACT This Phase II STTR project will develop Caduceus Quest, an interactive multimedia resource to promote knowledge and interest in careers in STEM and health. It includes a digital game and a table-top analog game. An initial prototype of the Caduceus Quest digital game was developed and tested over the course of our Phase I project. A multidisciplinary team from Resilient Games Stud ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Multiplexed wireless battery-free sensors for pediatric intensive care units (PICU).

    SBC: WEARIFI, INC.            Topic: NICHD

    Project Summary In the pediatric intensive care unit (PICU) monitoring of hemodynamics and oxygen transport provide critical information needed by care providers for decision making. Patients end up with so many wires, tubes and umbilicals that access to the patient and movement become limited. Furthermore, many of these monitoring techniques are invasive, and for the frailest patients in the PICU ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Low Burden Wearable Sensor System for Diagnosing Obstructive Sleep Apnea in Older Adults

    SBC: Sibel Inc.            Topic: NHLBI

    1 PROJECT SUMMARY: andgt;50% of adults aged 65+ have a high risk of obstructive sleep2 apnea (OSA), a condition that increases the risk of stroke, heart attack, and death. The3 prevalence of OSA is at least twice as high in older adults compared to younger age4 groups. Despite this increased risk and prevalence, only 8% of older adults at high risk5 of OSA receive evaluation by either in-laborator ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Real-time volumetric specimen imager for 3D intra-operative lumpectomy margin assessment

    SBC: Clarix Imaging Corporation            Topic: 102

    Abstract Clarix Imaging, Corporation (Clarix) is focused on solving one of the largest problems in early stage breast cancer treatment, reoperations for positive margins. About 25% of the andgt;200,000 patients who undergo lumpectomy in the US each year will face this additional procedure because current options for identifying positive margins intraoperatively are insufficient. Currently physicia ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Advanced wireless optogenetics and photometry system for neuroscience research

    SBC: Neurolux, Inc.            Topic: 101

    Project Summary/Abstract Neuroscience research over the last decade has been revolutionized by many technological advancements. Optogenetics and fluorescence imaging represent two distinct, and sometimes complementary tools used in neuroscience research to study the central and peripheral nervous systems in the context of the BRAIN initiative. Advanced interrogations of underlying neural circuits ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  7. A portable ultra-widefield fundus camera for nonmydriatic examination of retinopathy of prematurity

    SBC: Biolight Engineering LLC            Topic: N

    Title: A portable ultra-widefield fundus camera for nonmydriatic examination of retinopathy of prematurity Summary: Prompt screening is an essential step to prevent visual impairment and blindness due to retinopathy of prematurity (ROP). It is known that widefield fundus examination is essential for ROP screening, diagnosis and treatment evaluation. However, existing pediatric fundus cameras have ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. MR Virtual Pathology of the Prostate

    SBC: QMIS            Topic: 102

    QMIS, LLC (Quantitative MRI Solutions) is developing a new MRI-based tool that reliably screens for prostate cancer (PCa). PCa is a leading cause of death (29,500 U.S. deaths in 2018). Current methods (PSA and digital rectal exam) are unreliable; they result in unnecessary biopsies while missing clinically significant PCa. MRI has potential to detect PCa at an early stage when it is highly curable ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. A Proton Tomography System for Optimization of Proton Therapy

    SBC: ProtonVDA LLC            Topic: NCI

    Abstract Proton therapy is rapidly expanding in the United States. Currently, the calculation of proton range in proton therapy patients is based on a conversion of CT Hounsfield Units of patient tissues to proton relative stopping power. Uncertainties in this conversion necessitate larger proximal and distal planned target volume margins. These larger margins increase the dose to nearby healthy t ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: OD

    Abstract Duchenne Muscular Dystrophy (DMD) is a fatal muscle disease with a predicted incidence of 1 in 5000 males. DMD results from mutations in the gene encoding dystrophin, a 427 kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and laminin in the extracellular matrix. The 7β1 integrin is a transmembrane linkage system in skeleta ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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