Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A point of care test for TB antibiotic concentration in blood

    SBC: NANOCOMPOSIX INC            Topic: NIAID

    TuberculosisTBis one of the topcauses of death worldwideTB treatments include combinations of multiple antibiotics and dosage levels over a long period of timeOften the dose must be adjustedLow antibiotic blood concentrations may cause slow responseprolonged infection or treatment failureand the TB strain may acquire drug resistancetoo high and toxicity may be an issueCurrent technologies for meas ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. POC Diagnostic for Gonorrhea and Determination of Antimicrobial Susceptibility

    SBC: Visby Medical, Inc.            Topic: NIAID

    VisbyFormally know as Click Diagnosticshas developed a PCR based rapiddisposablepoint of care test that automatically performs sample processingPCR amplificationand amplicon detectionLeveraging the existing platformClick willfrom a single urogenital sampledetect NG and determine whether the infecting strain is susceptible to three classes of antibioticsciprofloxacincefiximeor a novel antibiotic zo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. New Carriers Used as Adjuvants for Controlled HIV Immunogen Delivery into Targeted Antigen Presenting Cells

    SBC: NANOCOMPOSIX INC            Topic: NIAID

    Despite the global impacts of HIV on human healthwith an estimatedmillion new cases each year andmillion people living with HIVan effective vaccine has not been developedThere are many challenges for HIV vaccine development including the virus s rapidly changing surface immunogens and the early integration of the virus into the host s genomeTo overcome these challengesa mesoporous silica adjuvant ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Mobile Health Point-of-Care Diaagnostics for Malaria

    SBC: Chromologic LLC            Topic: NIAID

    A resurgence of malaria infections has occurred in the USprimarily due to increasing global travelOnly wide spread screenings and treatments of endemic populations can prevent the return of malaria endemicityCurrentlythere is no diagnostic test that meets the need of highly sensitive malaria screening tool for low resource settingsTo address this needChromoLogic proposes to develop the Quick Mag p ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Evaluation of VesiVax Adjuvant Formulations for HIV Vaccines

    SBC: Molecular Express Inc            Topic: NIAID

    This proposal aim to develop a VesiVaxplatform based liposomal vaccine that can co formulate the HIV antigenHIV Env gpAwith various immunotimulatory adjuvant moleculesIAMsThe IAMs that we will formulate with the antigen includeslipidated tucaresolmuramyl tripeptide phosphatidylethanolaminePam CAGmonophosphoryl lipid AdsRNAandcyclic dinucleotidesThe formulations will be evaluated in miceand selecte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A smartphone-based point-of-care test for detection of influenza in low resource settings

    SBC: Luminostics, Inc.            Topic: NIAID

    Each yearinfluenza causes more thanhospitalizations and aboutdeaths in the U SPeriodicallypandemic strains of influenza emerge that cause even greater devastationthe most recent H Npandemic ofcausingdeaths in the U SDiagnostic testing for influenza is a critical component in managing the diseaseit offers data used in global influenza surveillance efforts and can help guide the treatment of individ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Rapid Nucleic Acid Test for the Point of Care Detection of Malaria

    SBC: Crosslife Technologies Inc.            Topic: NIAID

    We propose the development of a highly sensitivesimple paper strip molecular nucleic acid blood test that detects parasites causing malaria at the point of careThe final product to be developed in Phaseis an FDA approved nucleic acid based diagnostic device paper dipstick test that contains a multiplex of probe that can amplify and detect nucleic acid sequences from the gametocyte specific pfstran ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid diagnostic to determine CMV serological status

    SBC: NANOCOMPOSIX INC            Topic: NIAID

    The goal of this project is to develop a diagnostic that can support the enrollment of seronegative individuals in clinical trials of candidate cytomegalovirusCMVvaccinesCongenital CMV infection is one of the leading causes of non genetic birth defects worldwideIf a successful vaccine can be brought to marketit will have a significant impact on the number of babies born with hearing and vision los ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. EAP-Derived Monoclonal Antibodies or Phenotyping Immune Cells of Animal Models of Disease

    SBC: SILVER LAKE RESEARCH CORPORATION            Topic: NIAID

    The investigation of mechanismspotential treatmentsand vaccines for infectious diseases relies on animal models that can be infected by the same agent as humans and display similar symptomsIn many casessuch animals are not the typicalwell characterized research modelsbut rather non traditional speciesOne example of this situation is the ferret model of influenzaA major drawback of non traditional ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Sample Sparring Assay for Isolation and Analysis of Immune Cell Populations using Magnetic Ratcheting

    SBC: FERROLOGIX, INC.            Topic: NIAID

    Immunoassays which minimize sample usage are a critical need to develop personalized therapeutics like immunotherapy and precision immunomodulatory devicesThis often involves the isolation and analysis of specific cell types from blood or tissue samplesUnfortunatelythe current workflows needed to isolate these cell populations utilize magnetic cell sorting and or flow cytometry which are expensive ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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