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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

Displaying 1 - 10 of 6728 results
  1. TempO-Seq Profiling of RNA Epitranscriptomic Modifications

    SBC: BioSpyder Technologies, Inc.            Topic: 172

    This Fast Track Phase I-II SBIR addresses the NHGRI Special Interest Topic C: “Genomics tools ranging from new instruments to sophisticated molecular biology kits”. The recent discoveries of methylomes of reversibly methylated mRNA and early indications of the functional role these play in cellular function and disease, and the introduction of RNA immunoprecipitation sequencing (RIP-Seq) deriv ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Analytical Validation of Non-native Transthyretin (NNTTR) As A Candidate Biomarker for Transthyretin Amyloidoses (ATTR)

    SBC: PROTEGO BIOPHARMA, INC.            Topic: NINDS

    Project DescriptionThe transthyretin (TTR) Amyloidoses (ATTR) are progressive fatal diseases caused by the misfolding, aggregation and deposition of mutant and wild-type forms of TTR, a homotetrameric thyroxin transporting protein secreted by the liver, choroid plexus and retina. ATTR presenting as primary polyneuropathy (FAP) can affect the peripheral, autonomic and central nervous systems (CNS). ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Safety and efficacy of an allergy therapeutic targeting FcERI bound IgE in human immune reconstituted mice.

    SBC: Sixal Inc            Topic: NIAID

    PI - Andrew Saxon MD Abstract: The goal of this SBIRI application is to accomplish key “long term” safety and efficacy time-course studies of a novel biologic designed for the preventive treatment of all severe/IgE mediated food allergic reactions and mastocytosis. Allergic diseases and specifically severe food allergies have increased to the point of becoming a major worldwide public health p ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases

    SBC: Nanode Therapeutics, Inc.            Topic: NCATS

    STTR_Developing Nanopieces 7. Project Summary/Abstract The bottleneck of developing new RNAi (RNA Interference) drugs is the lack of highly efficient and non-toxic RNA delivery to non-liver tissues in vivo. It is especially challenging to deliver negatively-charged nucleic acid into avascular, dense, and negatively-charged matrix in hard-to-reach tissues including joint cartilage. NanoDe Therapeut ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. IND-enablingEpicardial Biopharmaceutical in the Diabetic Heart

    SBC: Regencor, Inc.            Topic: NHLBI

    ABSTRACT Diabetes mellitus (DM) is caused by inadequate insulin secretion or an inability to respond appropriately to secreted insulin, which leads to chronic elevated blood sugar levels (hyperglycemia). An estimated 171 million people worldwide have DM, and the prevalence of DM will more than double over the next 2 decades. Diabetic patients have increased rates, severity, and complexity of ather ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Caduceus Quest: An interactive digital media resource to promote knowledge of reproductive health and STEM

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: 500

    PROJECT ABSTRACT This Phase II STTR project will develop Caduceus Quest, an interactive multimedia resource to promote knowledge and interest in careers in STEM and health. It includes a digital game and a table-top analog game. An initial prototype of the Caduceus Quest digital game was developed and tested over the course of our Phase I project. A multidisciplinary team from Resilient Games Stud ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Temperature-Responsive Clips for Removable Dental Prostheses

    SBC: RODO MEDICAL, INC.            Topic: NIDCR

    ABSTRACT The American Academy of Implant Dentistry reports that about 70% of Americans between the ages of 35-44 have at least one missing tooth, and that one in four over the age of 74 lose all their natural teeth. The first choice treatment for patients with multiple or all of their teeth missing are overdentures, which are removable replacement teeth retained by dental implants. The main reason ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Material-guided delivery and local activation of bioorthogonal prodrugs

    SBC: Shasqi, Inc            Topic: 300

    ABSTRACT Systemic administration of small molecule therapeutics to treat disease can be ineffective, and even hazardous, because the drugs distribute widely in the body. This lack of site-specificity means large systemic doses are needed to achieve effective concentrations in the diseased tissues, but these high doses often result in non- specific toxicity. Roughly 1 in 20 hospitalized patients ex ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Targeted Gene Insertion by Directed Evolution of ΦC31 Integrase for Therapeutic Gene Editing

    SBC: Applied Stemcell, Inc.            Topic: 400

    Pain Point: Applied StemCell (ASC) is engineering ΦC31 integrase through directed evolution to establish the ability to site-specifically integrate exogenous DNA into the human genome. Currently, there are no gene editing technologies on the market that allow for efficient, site-specific insertion of large transgenes. CRISPR/Cas9, and other nuclease-based technologies – including TALENs and Zin ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. FoxWare™, An Advanced Data Analysis Package for Hydroxyl Radical Foot-Printing Higher Order Structural Analysis

    SBC: GENNEXT TECHNOLOGIES, INC.            Topic: 300

    The GenNext Phase II SBIR submssion entitled “FoxWare™, an Advanced Data Analysis Package for Hydroxyl Radical Foot-printing Higher Order Structural Analysis” is responsive to the ackowledged need for new and improved tools for higher order structural analysis (HOS) of biopharmaceuticals. Biopharmaceuticals are complex, heterogeneous mixtures of 3-dimensional biomolecules, whose safety and e ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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