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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Open-label extension of a 3-month blinded clinical trial of PTI-125

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary/Abstract PTI-125 is a novel small molecule Alzheimerandapos;s disease (AD) therapeutic candidate with a novel target and mechanism of action. PTI-125 binds and reverses an altered conformation of the scaffolding protein filamin A (FLNA) to prevent Aβ42andapos;s tight binding to and toxic signaling via the α7-nicotinic acetylcholine receptor (α7nAChR) as well as Aβ42andapos;s ab ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases

    SBC: Nanode Therapeutics, Inc.            Topic: NCATS

    STTR_Developing Nanopieces 7. Project Summary/Abstract The bottleneck of developing new RNAi (RNA Interference) drugs is the lack of highly efficient and non-toxic RNA delivery to non-liver tissues in vivo. It is especially challenging to deliver negatively-charged nucleic acid into avascular, dense, and negatively-charged matrix in hard-to-reach tissues including joint cartilage. NanoDe Therapeut ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Caduceus Quest: An interactive digital media resource to promote knowledge of reproductive health and STEM

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: 500

    PROJECT ABSTRACT This Phase II STTR project will develop Caduceus Quest, an interactive multimedia resource to promote knowledge and interest in careers in STEM and health. It includes a digital game and a table-top analog game. An initial prototype of the Caduceus Quest digital game was developed and tested over the course of our Phase I project. A multidisciplinary team from Resilient Games Stud ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Determination of optimal antisense oligonucleotide chemistry for efficient and safe splicing modulation in T cells

    SBC: Autoimmunity Biologic Solutions, Inc.            Topic: NIAID

    PROJECT SUMMARY Multiple Sclerosis (MS) is the most common neurological disease of early adulthood and is mediated by autoimmune mechanisms that lead to demyelination and neuronal damage in the central nervous system, resulting in progressive neurological dysfunction. There is no cure for the disease and current treatments focus on preventing future immunological attacks, mainly by suppressing the ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. A small molecule integrin activator to enhance cord blood transplant

    SBC: 7 Hills Pharma LLC            Topic: NHLBI

    PROJECT SUMMARY This proposal is in response to the parent announcement for Phase II STTR (R42) grant applications. Hematopoietic stem cell transplantation has become a preferred treatment for hematological malignancies and certain genetic disorders. Umbilical cord blood has become an appealing alternative to bone marrow or peripheral blood as a source of hematopoietic stem cells for transplant. D ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Non-invasive Detection of Cerebral Aneurysm Recurrence after Endovascular Treatment Using Automated Image Processing

    SBC: Medical Innovators Company, LLC            Topic: 101

    PROJECT SUMMARY Hemorrhage due to cerebral aneurysm rupture is a devastating condition with high mortality. For the more than 30,000 patients in the US who are diagnosed annually with an aneurysm, treatment consists of preventing rupture, and increasingly relies of endovascular techniques. However, treatment durability is unknown with recurrence estimated at 16-40% and the re-treatment of 10-20%. ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Rapid Test Kit for Measurement of Urinary Iodine

    SBC: Lynntech Inc.            Topic: NICHD

    Iodine is an essential component of the thyroid hormones which are necessary for normal growth, development, and metabolism during gestation, infancy, and throughout life. Iodine deficiency disorders (IDD) affect more than a billion people worldwide, and IDD during pregnancy and infancy are a major cause of intellectual impairment and brain damage. Iodine deficiency, through its effects on the dev ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Application of TNFRSF25 agonists for prophylaxis and treatment of graft versus host disease

    SBC: PELICAN THERAPEUTICS, INC.            Topic: NIAID

    PROJECT SUMMARY Graft-vs-Host-Disease (GVHD) is a frequent and life-threatening complication of hematopoietic stem cell transplantation (HSCT), a procedure that often represents the best treatment option for patients suffering from hematological malignancies. Even when HLA-matched family or unrelated donors are available, an unsatisfactorily high frequency (30-40%) of transplant recipients still d ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. BCMA-targeted Oncolytic Virus for Multiple Myeloma

    SBC: IcellKealex Therapeutics LLC            Topic: 102

    PROJECT SUMMARYWhile the clinical outcome of multiple myeloma (MM) patients has shown remarkable improvements over the past two decades, MM remains incurable for most patients. Thus, more efficacious therapies and novel strategies are urgently needed. Oncolytic (cancer destroying) vaccinia virus (VV) is an appealing addition to the current cancer therapies due to its preference for infecting and k ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Multiplexed wireless battery-free sensors for pediatric intensive care units (PICU).

    SBC: WEARIFI, INC.            Topic: NICHD

    Project Summary In the pediatric intensive care unit (PICU) monitoring of hemodynamics and oxygen transport provide critical information needed by care providers for decision making. Patients end up with so many wires, tubes and umbilicals that access to the patient and movement become limited. Furthermore, many of these monitoring techniques are invasive, and for the frailest patients in the PICU ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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