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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Noninvasive Functional Cortical Mapping with Innovative tEEG

    SBC: CREmedical Corp            Topic: 106

    PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A multivalent, easy-to-use product to mitigate and treat radiation exposure

    SBC: FIBROPLATE, INC            Topic: NIAID

    ABSTRACTThe threat of radiological and nuclear accidents or attacks demands for effective radiation medical countermeasuresMCMable to mitigate and treat the effects of exposure to ionizing radiationsHematopoietic acute radiation syndromeHRASand cutaneous radiation syndromeCRSpose severelife threatening risks to exposed individualsCurrently no effective radio mitigatorto be administered after radia ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Immunoassay for early diagnosis of mucormycosis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    Mucormycosis is one of the deadliest of the invasive fungal infectionsMucormycosis occurs most often in patients with hematological malignancies undergoing chemotherapypatients who have received hematopoietic stem cell transplants or patients with diabetes mellitusImproved diagnosis is the most frequently noted unmet need for management of the mucormycosis patientDelays in treatment increase the m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Developing, Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARYThis application for a Phase II SBIR award extends the successful completion of Phase I and represents acollaboration between ClinitechLLC and McLean Hospital Harvard Medical School to continue thedevelopment of a wearable biosensor for detecting alcohol in the interstitial fluid of humansExcessive use ofalcohol accounts for much of the public health burden related to alcohol use di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Soluble, solution-stable phospho-glucagon for hypoglycemic rescue

    SBC: Monon Bioventures LLC            Topic: 200

    PROJECT SUMMARY Hypoglycemiaa decrease in blood sugar levelsis a common occurrence for themillion Americans with diabetesIn severe hypoglycemiathe individual is at risk for diabetic coma and even deathAlthough these events can be managed using a glucagon emergency kitcurrent kits require a multi step procedure in which lyophilized glucagon is reconstituted and administered as an injectionEmergency ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Probiotic Platform to Treat Necrotizing Enterocolitis

    SBC: Scioto Biosciences Inc.            Topic: 300

    PROJECT SUMMARY Necrotizing enterocolitisNECis a devastating disease affecting premature infantsApproximatelyof infants born underg will develop the diseaseand mortality for affected infants isDespite decades of researchthe morbidity and mortality of the disease remain generally unchangedCurrent treatment and preventive approaches for NEC remain suboptimalwith no FDA approved therapies for the ind ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Prevention of White Matter Injury in Premature Infants

    SBC: Medosome Biotec, LLC            Topic: NICHD

    ABSTRACTUp toof low birth weight preterm infants manifest some form of periventricular white matter injuryPWMImaking it the most common form of brain injury affecting premature infantsPWMI is associated with significant morbidityas affected individuals may have profound intellectual impairment and cerebral palsyHighlighting the magnitude of PWMIeach year more thaninfants are born prematurely in th ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of non-invasive research and diagnostics platform for Alzheimer's disease based on plasma exosomes

    SBC: Tymora Analytical Operations, LLC            Topic: N

    PROJECT SUMMARY Almostmillion Americans currently live with Alzheimerandapos s diseaseADand this number is projected to increase tomillion byThe consensus is arising in the field that in order to treat AD effectivelyearly detection at the MCI stage is a mustThusthere is a critical need for a novel minimally invasive and cost effective diagnostic assay capable of such early detectionCell secreted e ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Fabrication of Large Area, Submicron and Deep Submicron Hard X-Ray Gratings

    SBC: General Optics, LLC            Topic: NIBIB

    PROJECT SUMMARY ABSTRACT Grating based x ray interferometric imaging has long been considered a promising technique to significantly enhance image quality at reduced radiation doseby detecting phase and scattering contrasts in addition to the absorptionX ray gratings are central components in x ray interferometersCommercially available x ray gratings have periods of andgtmwhich limits the sensitiv ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Developing a commercial charge detection mass spectrometer for MDa to GDa mass measurements

    SBC: MEGADALTON SOLUTIONS LLC            Topic: 400

    Project Summary This proposal describes key steps towards generating the first commercial charge detection mass spectrometerCharge detection mass spectrometryCDMSis an emerging technology that can measure the masses of large heterogeneous biopharmaceuticals and nanoparticlesCurrent commercial mass spectrometers measure the mass to charge ratiom zof ensembles of ions and require charge assignment t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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