List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. DEVELOPMENT OF NOVEL PDE4B INHIBITORS TO TREAT ALCOHOL USE DISORDER (SBIR PHASE II)

    SBC: CODEX BIOSOLUTIONS            Topic: NIAAA

    Development of Novel PDE B Inhibitors to Treat Alcohol Use Disorder

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Increased Expression of an HIV CJ505.664 SOSIP Envelope in Plants by Modulation of ER Chaperones

    SBC: Plant Vax, Inc.            Topic: NIAID

    The recombinant HIV SOSIP EnvelopeEnvtrimer is the leading HIV vaccine candidate but current production levels are low in mammalian cell lineslikely due to current trimer designs which include numerous disulfide bondsproteolytic cleavage and extensive glycosylationknown to induce endoplasmic reticulumERstress and cellular toxicityThis proposal will utilize the Nicotiana benthamiana pN bpplant expr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Low Cost Integrated Method for Isolation of M. Tuberculosis DNA from Raw Sputum

    SBC: AKONNI BIOSYSTEMS INC.            Topic: NIAID

    Nucleic acid testing offers the potential to improve tuberculosis diagnosis world wideHigh purity DNA is essential to the success of virtually any downstream nucleic acid detection methodWe propose to develop a sample preparation system to extract and purify Mycobacterium tuberculosis DNA from raw sputumThe project goalas described in the solicitationPHSTopicis to develop an inexpensive and easy t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC #384- PHASE I (FAST TRACK) SBIR CONTRACT- FINCARE: ENABLING PROVIDERS AND PATIENTS TO MAKE INFORMED CHOICES AND MINIMIZED FINANCIAL HARDSHIP

    SBC: CARE PROGRESS, LLC            Topic: NCI

    This research project seeks to create innovative software that aids healthcare providers to calculate the out of pocket costs of patients receiving cancer treatmentThe goals of this SBIR project are to leverage the insights of stakeholderssubject matter experts and industry standards to create a software system that can be integrated into the workflow of providersIf we are successfulhealthcare pro ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 385: CARE4AHEAD: CREATING A SCALABLE TECHNOLOGY SOLUTION TO IMPROVE LONG-TERM CARE FOR CANCER SURVIVORS- MOONSHOT

    SBC: CARE PROGRESS, LLC            Topic: NCI

    The goal of this SBIR project is to create a prototype of an innovative software system to help cancer survivors better manage their symptoms and stay connected with their clinicians over the course of their livesThis will include enabling survivors to report symptoms they may be experiencingcollect and transmit real time measurements from wearable sensors and receive notifications and reminders t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 383: MULTI-CORE BIOPSY DEVICE WITH VOLUMETRIC FIELD OF TISSUE ACQUISITION (MOONSHOT)

    SBC: Robin Medical, Inc.            Topic: NCI

    The problemTumor recurrence or resistance to treatment often arises due to tumor heterogeneityThere is a need to develop smart biopsy devicesto collect biopsies from multiple tumor coresto identify locations of the biopsiesto maintain physical characteristics of tumor on the extracted samplesto be used under current image guided practicesWe propose to further develop a prototype of multi core biop ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC #355- SBIR PHASE II- A 3D PERFUSABLE PLATFORM FOR HTS ACROSS DIVERSE RACIAL/ETHNIC CANCER SPE

    SBC: MIMETAS US, INC            Topic: NCI

    Prostate cancerPCaincidence and mortality in African American men is two times greater than men of other races ethnicities in the United StatesElucidating the underlying mechanisms for this cancer health disparityCHDis critical to patient treatment and improved patient outcomehowever there are no in vitro models available to adequately recapitulate the PCa tumor microenvironment across races ethni ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 368: TREATMENT OPTIMIZATION BY COMBINED A-EMITTER (ARPT)/RADIOTHERAPY (XRT) DOSIMETRY FOR PROSTATE CANCER PATIENTS

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: NCI

    We propose to demonstrate a cloud based software service for Combination alpha emitter radiopharmaceutical therapyRPTand external beam radiotherapyXRTCX RPTtreatment planningBoth modalities deliver radiationWe will demonstrate feasibility clinically by collecting the data needed from an existing Hopkins trial evaluating combination XRT with XofigoRa dichlorideanRPT that concentratesparticle radiat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 345: PREDICTIVE BIOMARKERS OF PROSTATE CANCER PATIENT SENSITIVITY FOR RADIATION LATE EFFECTS

    SBC: Shuttle Pharmaceuticals, Inc.            Topic: NCI

    To address the goals of developing ""predictive biomarkers of adverse reactions to radiation treatment""we propose to perform a multi site analytic validation of the product""metabolite panel kit""developed in the Phase I SBIR effortResults of plasma metabolite analysis in defined cohorts of patients treated with SBRT for prostate cancer will be tested for precisionaccuracy and reproducibility in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. SBIR PHASE I TOPIC 392: TARGETED RADIONUCLIDE THERAPY OF METASTATIC LIVER CANCER: PATIENT SPECIFIC OPTIMIZATION

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: NCI

    Radioembolization using Ymicrospheres delivered into the hepatic artery under fluoroscopy guidance has slowed tumor progression in the liver for patients diagnosed with metastatic colorectal cancermCRCTreatment planning is based on a simple estimate of the average absorbed doseADdelivered to the treated volumetumor dose thus depends on tumor burden and tumor to background ratioresulting in under d ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government