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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Noninvasive Functional Cortical Mapping with Innovative tEEG

    SBC: CREmedical Corp            Topic: 106

    PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A multivalent, easy-to-use product to mitigate and treat radiation exposure

    SBC: FIBROPLATE, INC            Topic: NIAID

    ABSTRACTThe threat of radiological and nuclear accidents or attacks demands for effective radiation medical countermeasuresMCMable to mitigate and treat the effects of exposure to ionizing radiationsHematopoietic acute radiation syndromeHRASand cutaneous radiation syndromeCRSpose severelife threatening risks to exposed individualsCurrently no effective radio mitigatorto be administered after radia ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Combinatorial Biomarkers for Malignant Polyps and Colon Cancer Detection

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 102

    ABSTRACT Technological advancements in colonoscopic and polypectomy procedures have drastically reduced both the incidence and overall mortality due to colorectal cancerCRCHowevereven with the availability of multiple screening toolsonlyof CRC are diagnosed at early stagein part due to lack of compliance with follow up colonoscopy procedurelimited access to colonoscopyThese factors contribute to i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Immunoassay for early diagnosis of mucormycosis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    Mucormycosis is one of the deadliest of the invasive fungal infectionsMucormycosis occurs most often in patients with hematological malignancies undergoing chemotherapypatients who have received hematopoietic stem cell transplants or patients with diabetes mellitusImproved diagnosis is the most frequently noted unmet need for management of the mucormycosis patientDelays in treatment increase the m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Developing, Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARYThis application for a Phase II SBIR award extends the successful completion of Phase I and represents acollaboration between ClinitechLLC and McLean Hospital Harvard Medical School to continue thedevelopment of a wearable biosensor for detecting alcohol in the interstitial fluid of humansExcessive use ofalcohol accounts for much of the public health burden related to alcohol use di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a lead cyclic-PDZ-Enhancer drug for Anxiety and Depression

    SBC: Aingeal, LLC            Topic: 101

    Major depressive disorder is a debilitating mood disorder that affectsof US adults in their lifetimecosting the U Seconomy more than $billion a yearDrugs that increase monoaminergic signaling are the mainstay of depression therapybut have a delayed onset of action and are only effective in aboutof affected patientsAberrant brain derived neurotrophic factorBDNFsignaling has been proposed to underli ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Personalized Bioreactor for Cell Culturing in Alginate Tubes

    SBC: CellGro Technologies, LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Lateral flow immunoassay for rapid diagnosis of tinea capitis and onychomycosis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitisringworm of the scalpand onychomycosisfungal nail infectionare infections that are most often caused by dermatophytes of the fungal genera Trichophyton and MicrosporumThese two infections affect approximatelymillion people in the U Seach yearDermatophyte infections of the hair and nails are treated with oral antifungals for up toweeksDue to potential adverse effectsboth the American A ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Fourth Trimester- A web-based tool for Postpartum Care to Address the Needs of Underserved Women

    SBC: Orange Square Design, Inc.            Topic: NIMHD

    PROJECT SUMMARY ABSTRACT In the United Statesthe postpartum period is a critical time for both maternal and child healththe mortality rate is the highest among other developedhigh income countries and more than half of all maternal deaths occur postpartumfrom one day to one year after birthThis poor outcome is linked to the racial and ethnic disparities that disproportionately effect black women w ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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