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DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION provided by applicant Trichomonas vaginalis is the causative agent of the most common non viral sexually transmitted infection with million new cases reported annually in the world and million cases in the U S In addition to infections of the urogenital tract trichomoniasis increases the risk of adverse pregnancy outcomes and HIV transmission and increases the incidence ...

DESCRIPTION provided by applicant Our laboratory discovered and is developing partial p MHC class II constructs pMHC as a possible immunotherapy for multiple sclerosis MS pMHC containing the extracellular domains of the MS risk factor HLA DR linked covalently to the encephalitogenic peptide of myelin oligodendrocyte glycoprotein pDR MOG can reverse CNS inflammation and ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant The nematode Caenorhabditis elegans is a powerful experimental system that is widely used as a model for a large number of high impact medical conditions from aging and metabolic disorders to neurodegenerative diseases The strength of this microscopic worm as a medical model derives from the extensive genetic homology between nematodes and humans together ...

DESCRIPTION provided by applicant The proposed project will develop ESCALA Escuela y Carrera Latina Latino School and Career a mobile web app designed to increase the college and lowest educational attainment in the United States Because educational attainment is a major social determinant of health it is not surprising that Latinos also experience poor health outcomes compared to white ...

DESCRIPTION provided by applicant Approximately of women experience postpartum depression PPD which results in significant suffering for new mothers and their families and has an adverse impact on infant development Fortunately effective treatments for PPD have been developed and validated However there are many barriers that make it difficult for women with PPD to access clinic ...

Project Summary Pertussis is rapidly re emerging as a serious public health threat in the United StatesDespite high vaccine coverage nationallyannual reported cases in the U Shave been increasing recentlywith ayear high ofinMoreoverreported cases represent a large underestimate of pertussis infectionsDiagnosis of early pertussiscatarrhal stageprior to paroxysmal coughis particularly challenging be ...

DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

Abstract The Madrina NetworkWeb PortalA Healthy WeightHealthy Lifestyle Intervention for Latinas Ana Consuelo MatiellaPIACMA Social Marketing This Fast Track application addressesa serious health disparityi ethe crisis of obesity among Latinasin the United Statesand the dire need of a timely and culturally and linguistically appropriate weight lossinterventionThis innovative research grant is in d ...