Award Data

DESCRIPTION provided by applicant Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme GBM high grade glioma a deadly and invasive brain tumor with no effective treatment Of the patients expected to be diagnosed with GBM this year most will succumb within a year There is an urgent demand for an efficac ...

DESCRIPTION provided by applicant The significance of the proposed research is based on the growing demand for healthcare resources to treat and manage prostatic disease particularly benign prostatic hyperplasia BPH and cancer Both the incidence and cost of treatment for BPH and its complications are growing rapidly with the aging U S population prostate cancer is the second leading cau ...

DESCRIPTION provided by applicant This project aims to demonstrate that the evolution of plant biosynthetic pathways can be accelerated and driven to favor the synthesis of ligands which interact with a specific human target protein This is achieved by subjecting mutant plant cells to selection pressures favoring the survival of mutants with the phenotype of interest As an example this appro ...

DESCRIPTION provided by applicant The broad long term objective of the proposed research is to develop and market a commercial software product that can be used to facilitate the analysis of genetic changes in order to elucidate chromosomal abnormalities that underlie diseases such as autism spectrum disorder bipolar disorder and schizophrenia Recent technological advances allow samples of ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

Emerging infrared (IR) sensor assets will play a crucial role in creating a robust and flexible Ballistic Missile Defense System (BMDS) because they are more easily deployed in forward-based and/or space-based environments, providing coverage of threats beyond the range of terrestrial sensors, and enabling launch-on-remote or engage-on-remote firing doctrines that extend the range of weapons syste ...

The Elicitor tool developed under this SBIR will significantly reduce the time and manpower necessary to effectively elicit, characterize and analyze stakeholder needs. It will enable effective requirements generation and allocation to appropriate baselines, and it will reduce redundant efforts among the intended uses a system. By design, the tool directly addresses the understood requirement th ...

This project targets the development of a commercially viable silicon-nitride (SiN) Atomic Layer Deposition (ALD) process for gallium nitride (GaN) Monolithic Microwave Integrated Circuits (MMICs) applications. In particular, this project will provide a higher quality substitution for commonly used PEVCD SiN passivation layers. These better passivation layers will enable the development and manufa ...

In this Phase II STTR proposal we will demonstrate the scalability and ruggedness of the production system necessary for the commercialization of the goose egg-derived immunoglobulin product that is a countermeasure to the lethal (40 %) Hantavirus Pulmonary Syndrome caused by Andes Virus (ANDV). A major objective will be creating a Quality System (QS) around the global process that aligns it with ...

ABSTRACT: In response to the U.S. Air Force"s need for fiber cooling and pointing in high power fiber amplifiers of 1kW and up, i2C Solutions propose the development of a conformal thermal ground plane (TGP) technology to interface with heat sinks integrated into the active precision pointing fiber support structure. The result is a highly efficient thermal management solution, with respect to b ...