Award Data

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant This study will aim to assess the feasibility and acceptability of using state of the art social media and game technology to increase HIV testing among adolescents and young adults AYA ages Rates of HIV testing among AYA are low resulting in high proportions of AYA who are positive or unaware of their HIV infection Further public health messages wh ...

Project Summary Pertussis is rapidly re emerging as a serious public health threat in the United StatesDespite high vaccine coverage nationallyannual reported cases in the U Shave been increasing recentlywith ayear high ofinMoreoverreported cases represent a large underestimate of pertussis infectionsDiagnosis of early pertussiscatarrhal stageprior to paroxysmal coughis particularly challenging be ...

DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

DESCRIPTION provided by applicant Smoking kills Americans annually exacerbates myriad diseases and costs billions in healthcare and productivity losses Numerous barriers exist to accessing traditional treatment e g costs traveling to and scheduling appointments other logistics Text messaging is an extremely popular communication method Over of all Americans use text m ...

ABSTRACT Endometriosis is a highly prevalent gynecologic disease characterized by severe pelvic pain and infertility that negatively impacts the wellbeing and quality of life of millions of women worldwide Despite decades of basic and clinical research on endometriosis there is limited understanding of its pathophysiology and no specific non invasive diagnostic assays are available ...

Project Summary Antibodies can facilitate the study of associations between different proteins in the cell using a technique known as immunoprecipitation IP This approach can reveal differences in protein associations present in healthy vs diseased tissues provide targets for diagnostics and therapeutics and reveal protein protein interfaces that could be druggab ...