Award Data

DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

DESCRIPTION (provided by applicant): Calista Therapeutics has discovered a first-in-class, proprietary PDZ1-2 lead drug, AT010, that is being optimized and developed as an inhaled daily therapy for cystic fibrosis (CF). CF is a deadly inherited genetic disorder that disrupts chloride channel function, resulting in the buildup of sticky mucus in patient's lungs and other organs.CF patients hav ...

DESCRIPTION (provided by applicant): Chronic musculoskeletal pain creates a significant public health burden. Veterans are disproportionately affected by chronic musculoskeletal pain, and in particular, chronic low back pain (CLBP). The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), and all three conditions (Post-deployment Multi-symptom Disorder (PM ...

DESCRIPTION (provided by applicant): Researchers and contractors are under increasing pressure to produce rapid turnaround times for data releases and publications. Inadequate data management is a common threat to good research and impedes the quick release of high value data. Despite its importance, many organizations do not have standardized data management practices that allow them to prepare h ...

DESCRIPTION (provided by applicant): EIderly falls constitute one of the most costly health problems in the U.S., both in terms of expense to the healthcare system and in individual suffering. Fully one-third of people over age 65 fall each year, many incurring significant injuries that strongly impact their long-term health prospects and productivity. Although many factors contribute to the prop ...

DESCRIPTION (provided by applicant): EIderly falls constitute one of the most costly health problems in the U.S., both in terms of expense to the healthcare system and in individual suffering. Fully one-third of people over age 65 fall each year, many incurring significant injuries that strongly impact their long-term health prospects and productivity. Although many factors contribute to the prop ...

DESCRIPTION (provided by applicant): A computer controlled switching stimulator/amplifier is proposed which is capable of delivering electrical stimuli between pairs of intracranial electrodes, while simultaneously monitoring the EEG potentials on all implanted electrodes immediately before and after stimulus application In phase 1, a key feasibility issue will be to study the electro-chemical ef ...

DESCRIPTION (provided by applicant): Bacterial contamination of blood products is currently a major problem in transfusion medicine and a leading cause of transfusion-related deaths. Platelets are particularly susceptible to contamination because they are stored at room temperature. BCR Diagnostics, Inc. (BCR) has developed a novel biosensor platform for detecting low levels of bacteria in r ...

DESCRIPTION (provided by applicant): The ability to evaluate the performance of seat cushions is critical to the development of wheelchair seating and standards, and to the selection of cushions by consumers and therapists. To assess the ability of a wheelchair cushion to distribute pressure, the Skeletal Embedded Loading Indentor (SKELI) was designed to simulate both the soft tissue and bony skel ...

DESCRIPTION (provided by applicant): A feasibility study for the development of a friction drive inclined platform lift will be conducted. The proposed approach will utilize a twenty-year old design that was never sold commercially due to cost ineffectiveness, and nonconformance to safety regulations. This project's main technical innovation will be to replace the major cost component of the twen ...