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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 380- QIDS: Using Radiomics to Impact Radiotherapy Treatment Planning- Moonshot

    SBC: HealthMyne, Inc.            Topic: NCI

    HealthMyne proposes developing a Clinical Decision Support tool to be used in the point-of-care workflow for the Radiation Oncologist that uses radiomic features that have evidence-based association to disease course and/or normal organ damage, in order to impact the treatment planning process. Phase 1 will focus on extraction, calculation, and validation of identified radiomic features for lung c ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Computerized Screening for Comorbidity in Adolescents with Substance or Psychiatric Disorders

    SBC: KOBAK, KENNETH A            Topic: 104

    Project Summary This is a supplementalrenewalgrant to the Phase II SBIR grantComputerized Screening for Comorbidity in Adolescents with Substance or Psychiatric DisordersSince the funding of the Phase I granttwo significant developments occurred in the fieldthe American Psychiatric Association s release of the DSMmanualand NIMH s launch of the Research Domain CriteriaRDoCinitiative that aims to cr ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development of a cell based assay to assess antigen specific tolerance

    SBC: SALUS DISCOVERY LLC            Topic: R

    Project Summary Despite advances in the field of transplantation that have curbed acute rejection through immunosuppressive drugs and better control of infection and ischemia reperfusion injurychronic allograft rejection is still a major obstacle for successful organ transplantationSuccessful organ transplantation appears to require a balanced function of effector and regulatory T cellsTregto prev ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Synthetic hydrogels for biomanufacturing of iPSC-derived neural cells for precision medicine

    SBC: Stem Pharm, Incorporated            Topic: 106

    Project Summary Abstract Human neural cells manufactured using patient derived induced pluripotent stem cellsiPSCshold great promise for modeling neurodevelopmental disordersdiscovering new precision therapiesand screening for potential risks from environmental toxinsHoweverbiomanufacturing of neural cells and tissues is severely limited by low efficiencypoor reproducibilityand extended timeframes ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of a novel highly effective influenza vaccine

    SBC: Flugen, Inc.            Topic: NIAID

    Seasonal influenzafluvirusan NIAID category C priority pathogencauses widespread infectionresulting in at leastmillion cases of severe illness anddeaths worldwideWhile annual vaccination is recommended for all individuals aged overmonths in the UScurrent vaccines are only aroundeffective and there is an urgent need for safemore effective influenza vaccines that offer broad spectrum protectionTo me ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. RAPID: An Extremely Fast Monte Carlo Dose Computing Software for Nuclear Medicine

    SBC: Voximetry            Topic: 100

    PROJECT SUMMARY and ABSTRACT The clinical outcome of radiation therapy depends on delivering the highest possible absorbed dose to the tumor swhile limiting the dose to normal tissuesUnfortunatelyunlike external beam radiotherapyEBRTcurrent RT prescription methods do not consider absorbed dose to individual patients but instead use empirically derived or standard methodsThusup toof these patients ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. A Novel Myeloperoxidase Inhibitor for Treating Multiple Sclerosis

    SBC: ReNeuroGen LLC            Topic: 102

    Abstract Multiple sclerosisMSis an inflammatory demyelinating disease of the central nervous systemCNSIt is the most common autoimmune disease affecting the CNSAlthough much attention has focused on the immunological mechanisms in MSnew evidence suggests that oxidative stress also induces MS neuropathologyMyeloperoxidaseMPOis a powerful peroxidative enzyme that has long been considered a therapeut ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Selection and Development of a Lead Biologic for Treating Mitochondrial Disorders

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos sRecent discoveries support that mitochondrial dysfunction can be overcome to treat age related declineCyteGenandapos s hypothesis is that exercise induces the secretion of bloodborne proteins that act system ...

    STTR Phase I 2018 Department of Health and Human Services

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