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A STUDY IS PROPOSED WHICH WILL DETERMINE THE FEASIBILITY OF DEVELOPING A COMPUTER BASED MODEL FOR ADMINISTERING ASSESSMENT AND THERAPY TO MENTALLY RETARDED/DEVELOPMENTALLY DISABLED INFANTS AND CHILDREN. THE PRINCIPAL AIM OF PHASE I IS TO SURVEY CURRENT TECHNOLOGIES AS THEY RELATE TO THERAPY AND PROVIDE A BASIS FOR A PHASE II RESEARCH PLAN. HARDWARE AND SOFTWARE BASED SIMULATION OF A MODEL WILL BE ...

AN ADVERSE REACTION TO A DRUG WHICH TAKES PLACE WHILE A PATIENT IS ON MEDICATION IS OFTEN IMPOSSIBLE TO DIAGNOSE ACCURATELY. THE NATURE OF THE UNDERLYING REACTION MAY HAVE AN IMMUNOLOGIC, TOXICOLOGIC, OR PHARMACOLOGIC BASIS. AMONG THE MOST NOTABLE IMMUNOLOGIC REACTIONS TO DRUGS ARE THOSE WHICH GIVE RISE TO ANTIBODIES THAT, IN THE PRESENCE OF DRUG, ATTACH TO BLOOD CELLS AND DESTROY THEM. THE MOST C ...

BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH). IT HAS BEEN SHOWN TO BE A NATURALLY OCCURRING OPIATE, AS WELL AS TO POSSESS NONOPIATE RELATED BIOACTIVITY. CURRENT ASSAY TECHNIQUES ARE INADEQUATE DUE TO LACK OF IMMUNOLOGICAL SPECIFICITY RESULTING FROM CROSS-REACTING OF BE AND BLPH WITH THE SAME ANTIBODIES. A SEPARATION METHOD UTILIZING THE S ...

THE FORMATION OF DNA-CARCINOGEN ADDUCTS IS AN IMPORTANT ENVIRONMENTAL FACTOR IN CARCINOGENESIS. RECENT TECHNIQUES FOR ISOLATION AND CHARACTERIZATION OF DEOXYNUCLEOSIDE-CARCINOGEN ADDUCTS AND SUBSEQUENT IMMUNOASSAY PROCEDURES CAN EFFECTIVELY DETECT THESE ADDUCTS FROM CELL LYSATES IN THE RANGE OF 1 ADDUCT/107 BASES. WE WILL USE OUR COMBINED TECHNICAL EXPERTISE IN THE AREAS OF NUCLEOTIDE/NUCLEOSIDE C ...

A MODEL SYSTEM IS CREATED TO DETERMINE THE FEASIBILITY OF DEVELOPING INTEGRATED COMPUTER SOFTWARE FOR ANATOMIC PATHOLOGY MANAGEMENT INFORMATION. THE SOFTWARE COMBINES SEVERAL UNIQUE DIAGNOSTIC CODING FUNCTIONS, IS TRANSPORTABLE TO THE MAJOR COMPUTER ARCHITECTURES, AND IS EFFICIENT THE OBJECTIVES ARE TO: 1. INTEGRATE APPLICABLE PATIENT INFORMATION OBTAINED AUTOMATICALLY FROM HOSPITAL SOURCES DIRECT ...

THE SPECIFIC AIM OF THIS RESEARCH PROJECT IS TO DEVELOP A METHODOLOGY WHICH INCORPORATES TECHNOLOGICAL INNOVATIONS TO ENHANCE THE PERFORMANCE OF THE HOME HEALTH NURSE IN PROVIDING CARE FOR THE ELDERLY IN THEIR OWN HOME. PHASE I WILL CULMINATE IN 1.THE DEVELOPMENT OF A DATA COLLECTION INSTRUMENT FOR THE IDENTIFICATION OF THE LEARNING NEEDS AND LEARNING STYLE PREFERENCE FOR THE HOME HEALTH NURSE; 2. ...

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QUALITATIVE ADVANCES IN COMPUTER TECHNOLOGY HAVE LEVELED OFF SUFFICIENTLY TO JUSTIFY THE DEVELOPMENT OF A MULTI-USER, MULTI-FUNCTION, COMPREHENSIVE VISUAL TESTING INSTRUMENT FOR OPHTHALMOLOGISTS, VISUAL SCIENTISTS, AND OPTOMETRISTS. SUCH A SYSTEM COULD BE DEVELOPED WITH RELATIVE EASE WERE IT NOT FOR THE INDUSTRY STANDARD REFRESH RATE FOR GENERATING VIDEO IMAGES. UNFORTUNATELY, 60 HZ IS TOO SLOW FO ...

IN CANCER CLINICAL TRIALS^ADAPTATION OF DABYL REPEATABLE RADIOTHERAPY, AND REDUCE THERAPIST SETUP TIMES.TRIPOS IS THE LEADING SUPPLIER OF INTERACTIVE 3-D GRAPHICS-BASED MOLECULAR MODELING SOFTWARE, USED PRIMARILY IN PHARMACEUTICAL RESEARCH. IN COLLABORATION WITH JERI1, TRIPOS HAS ALSO BEEN DEVELOPING AN INTERACTIVE 3-D GRAPHICS-BASED STATISTICAL SOFTWARE PACKAGE, PROVISIONALLY KNOWN AS DABYL, WHIC ...