Award Data

LOCAL GOVERNMENT AND PUBLIC INSTITUTIONS IN RURAL AREAS ARE FACED WITH COMMUNICATION GAPS IN THE GATHERING, SHARING, ANDDISSEMINATION OF INFORMATION DUE TO CHANGES IN THE CO COMPLEXION AND NEEDS OF THEIR CONSTITUENCY, NEW LEGISLATION,TECHNOLOGICAL ADVANCEMENTS, SOCIAL CHANGES TURNOVERS IN IN LEADERSHIP, AND CHANGES IN THE ECONOMY. UNDER PHASE I, WE PROPOSED TO ESTIBLISH THE TECHNICAL MERIT AND FEA ...

THE PHASE I EFFORT IS TO ESTABLISH THE TECHNICAL MERIT AND FEASIBILITY OF USING VOICE MESSAGING TECHNOLOGY AS AN INST INSTRUCTIONAL TOOL FOR TRAINING HANDICAPPED PEOPLE WHO DE DESIRE TO START A BUSINESS OF THEIR OWN. THE HYPOTHESIS OF THE STUDY IS: USING VOICE MESSAGING TECHNOLOGY, IT IS POSSIBLE TO DEVELOP AN EFFECTIVE TRAINING PROGRAM FOR A NATIONWIDE AUDIENCE OF NEW AND FUTURE HANDICAPPED ENTRE ...

THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B. WORKING IN COLLABORATION WITH A SYNTHETIC ORGANIC CHEMISTRY GROUP AT WEST VIRGINIA UNIVERSITY, WE HAVE DETERMINED THAT THE PARENT COMPOUND, MFBL, HAS EXTENSIVE IMMUNE POTENTIATING ACTIVITY. OUR PROJECT WILL ANALYZE FIVE NEW DERIVATIVES OF L- ...

AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.THIS PROJECT INVOLVES DETERMINING THE ABILITY OF A NEW CLASS OF SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRM) KNOWN AS METHYLFURYLBUTYROLACTONES (MFBL) TO AUGMENT THE PRODUCTION OF LYMPHOKINES (IL-2, B-CELL GROWTH FACTOR, AND IMMUNE INTERFERON) AND MONOKINES (IL-1, PROSTAGLANDINS, AND CYTOLYTIC FACTOR). OUR LABORATORY HAS DETERMINED THAT ...

ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC IMMUNE RESPONSE MODIFIERS CAPABLE OF ACTIVATING SEVERAL COMPONENTS OF IMMUNE RESPONSE WITH NEGLIGIBLE T ...

THE INNOVATION INVOLVES THE DESIGN OF A SYSTEM (TO BE REFERRED TO AS A THERMAL PRECOLLIMATOR) TO PROVIDE A THERMALGRADIENT IN FRON OF GRAZING INCIDENCE X-RAY TELESCOPES WHILEMINIMIZING OBSCURATION OF THE TELESCOPE FIELD-OF-VIEW. THE SYSTEM SHOULD OCCUPY A MINIMUM OF SPACE (3 INCHES) ABOVE THE TELESCOPE AND IT SHOULD BE DESIGNED NOT TO DISTORT DUE TO THERMAL GRADIENTS AND THEREBY CHANGE THE PERCENT ...

THE PROVEN CLINICAL EFFECTIVENESS OF CISPLATIN AS WELL AS SEVERAL SECOND GENERATION ANALOGS HAS ESTABLISHED THE ROLE OF METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY. COMPLEXES OF METALS OTHER THAN PLATINUM HAVE BEEN OFTEN POORLY DESIGNED BECAUSE THEY WERE MODELED AFTER THE ACTIVE PLATINUM COMPLEXES WITHOUT CONSIDERING THEIR DIFFERENT THERMODYNAMIC AND KINETIC PARAMETERS. IN PARTICULAR, PALL ...

THE OBJECTIVE OF THIS STUDY IS TO SYNTHESIZE, CHARACTERIZE, AND EVALUATE BIOLOGICAL PROPERTIES OF POLYMERIC PLATINUM COMPLEXES IN AN EFFORT TO ENHANCE SOLUBILITY AND STABILITY WHILE REDUCING TOXICITY AND OBTAINING GREATER SUSTAINED ACTIVITY THAN THAT FOUND WITH ACTIVE, STRUCTURALLY RELATED, MONOMERIC COMPLEXES. THE PHASE I RESEARCH PLAN IS BASED ON THE PROMISING PRELIMINARY IN VIVO RESULTS OBTAINE ...

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TAC PROPOSES TO STUDY THE FEASIBILITY OF DETECTION AND LOCALIZING OIL DRUM SIZE OBJECTS ON/IN THE BOTTOM OF SURF ZONES. THE APPROACH IS TO ANALYZE THE PERFORMANCE PROBABILITIES AND DESIGN FEASIBILITY OF LOW FREQUENCY (20 TO 500 HZ) ACTIVE ELECTROMAGNETIC DESIGNS IN A TOWABLE, SUBMERGED HYDROFOIL CONFIGURATION. DETECTION SYSTEMS WOULD BE SUPPLEMENTED FOR LOCALIZATION BY EITHER NAVIGATIONAL FIX METH ...