Award Data

There are many cases where detection of the presence of a DNA or RNA sequence in a sample can rapidly and unambiguously identify bacterial and viral bioagents of concern or be used in the diagnosis of both inherited and infectious diseases. Traditional DNA/RNA analysis methods are not applicable for field-use or a routine environment because they require complex procedures, large instruments, and ...

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CURRENT MORPHOMETRY AND IMAGE ANALYSIS SYSTEMS CAN BE BROADLY DIVIDED INTO THOSE WHICH DISPLAY AN IMAGE AND REQUIRE THE USER TO TRACE THE POINTS OR LINES CONSIDERED SIGNIFICANT, AND THOSE WHICH APPLY COMPLEX ALGORITHMS TO LOCATE SIGNIFICANT OBJECTS AUTONOMOUSLY. WE SEE A NEED FOR AN INTERMEDIATE TYPE OF SYSTEM IN WHICH THE USER COULD RAPIDLY INDICATE THE APPROXIMATE LOCATION OF SIGNIFICANT OBJECTS ...

MANY SPECIALTY CHEMICALS AND NEW PHARMECEUTICALS ARE SECONDARY METABOLITES SYNTHESIZED BY RESTRICTED GROUPS OF MICROORGANISMS. IN THE COURSE OF COLLECTIN MICROBES FOR INDUSTRY, MYCOSRESEARCH ISOLATES MANY UNTESTED FUNGI THROUGH THE APPLICATION OF NOVEL, PROPRIETARY FUNGAL ISOLATION TECHNIQUES. LACK OF KNOWLEDGE CONCERNING THE GROWTH REQUIREMENTS OF UNUSUAL FUNGI HAMPER OUR EFFORTS TO MAINTAIN THEM ...

A functional assay system for monitoring antithrombin drugs, such as recombinant hirudin andhirudin analogs, in patients will be developed. This assay system will be based on a novel dry reagentparamagnetic particle-based assay technology that has recently been applied successfully to wholeblood, bedside monitoring of prothrombin time and activated partial thromboplastin time testing. Thedry reage ...

THE SUCCESSFUL DEVELOPMENT OF RELIABLE, LARGE-SCALE, HATCHERY TECHNIQUES FOR THE HAWAIIAN BLACK-LIP PEARL OYSTER NOW OPENS UP THE POTENTIAL FOR BLACK PEARL FARMING IN NEW AREAS ACROSS THE PACIFIC. EFFICIENT, COST-EFFECTIVE, GROW-OUT TECHNIQUES NEED TO BE DEVISED FOR THE HIGH-ENERGY MARINE CONDITIONS IN HAWAII AND OPEN ATOLL LAGOONS OF THE U.S.-AFFILIATED PACIFIC. CULTURE TRIALS WILL COMPARE TRADIT ...

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WE PROPOSE TO DEVELOP AN IMMUNOASSAY FOR THE PESTICIDE, CARBOFURAN. PHASE I WILL CONSIST OF SYNTHESIZING SUITABLE HAPTENS, CONJUGATING THESE HAPTENS TO AN IMMUNOGENIC CARRIER, PREPARING AND SCREENING RABBIT ANTISERA, AND CONDUCTING PRELIMINARY COMPETITIVE ELISA TESTS TO DEMONSTRATE THE FEASIBILITY OF THIS APPROACH TO A RAPID, ECONOMICAL PESTICIDE DETECTION SYSTEM.

Dengue virus causes dengue fever, a debilitating illness marked by high fever, headache, muscleand joint pain, and rash. The more severe forms of the illness, dengue hemorrhagic fever and dengueshock syndrome, are life threatening and are a principal cause of hospitalization among children inSoutheast Asia. Globally, the four serotypes of dengue are responsible for up to 100 million infectionsannu ...

The neurotoxins of Clostridium botulinum are the most lethal proteins known. The bacterium is ubiquitous, and thus rapid, reliable, sensitive, and cost-effective assays are needed to detect the toxin. Current immunoassays provide a rapid means to detect the neurotoxin. Their sensitivity, however, is limited by the affinity of the detecting antibody. The objective of this research, therefore, i ...