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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Clinical Development a Therapeutic Agent for COPD

    SBC: BIOMARCK PHARMACEUTICALS, LTD            Topic: N/A

    Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, there presently are no effective therapies to control excess mucus secretion in these diseases, and very few potential therapeutic targets. We discovered that a ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  2. IDENTIFICATION OF NEW ACETYL-COA CARBOXYLASE INHIBITORS

    SBC: CROPSOLUTION, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis and its product, malonyl-CoA, inhibits fatty acid oxidation. These functions make ACC a prime target for the development of therapeutics to treat obesity and type 2 diabetes. Knockout studies in mice, and animal studies with ACC inhibitors, have validated this approach. The most po ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Insulating Coatings for Implant Devices and Ribbon Cables

    SBC: PREMITEC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Summary Advancements in device miniaturization, integrated circuits packaging, microfabrication technologies, and biocompatible materials have made possible the development of complex neural prostheses designed to restore lost functions such as movement, hearing or vision. Neurological diseases result in significant impairment for millions of individuals worldw ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Improved Orthopedic Implant Surface Coatings

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Many contemporary medical and dental therapies include the replacement or repair of tissues using materials such as metal. Currently there are at least 150,000 hip replacements, 300,000 knee replacements, and 500,000 dental implant procedures performed in the US each year (Kurtz, Mowat et al. 2005). These numbers are expected to increase as the baby boom gen ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Nanoliter Lab-on-a-chip for Protein Crystallization

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Functional Health CAT in Chronic Kidney Disease

    SBC: QUALITYMETRIC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to apply item response theory (IRT) and computerized adaptive testing (CAT) to achieve major advances in the standardization of Chronic Kidney Disease (CKD) health-related quality of life (HRQOL) metrics, in the efficiency of data collection and processing technologies, and in the usefulness of clinician and patient reports. In contrast to static ins ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Nanoliter Lab-on-a-Chip for Blood Diagnostics

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Spectroscopic presciption verification system

    SBC: CENTICE CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Prescription dispensing errors at a pharmacy are a problem on a national level, at a rate of about 4 errors per day in a pharmacy filling 250 prescriptions daily. This translates to a gigantic amount of 51 million prescription errors per year with about 3 billion prescriptions being filled. There are as many as 7,000 deaths reported annually in the United State ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. Computerized Adaptive Assessment of Headache Impact

    SBC: QUALITYMETRIC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose a tool for evaluating the functional impact of headaches that uses computerized adaptive testing (CAT) to achieve more practical and more precise assessments by matching the questions to each patient's headache severity level. In previous work, we developed a headache impact item bank that improved score precision and validity and provided measuremen ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  10. Video-Based Coping Skills Training for Caregivers

    SBC: WILLIAMS LIFESKILLS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In the just-completed Phase I, and as detailed in our Phase I Final Report (Appendix I), we have shown it is feasible to create a module of a Video that includes scenarios that are more relevant to the problems faced by Caregivers. We also have shown that it is feasible to recruit Caregivers of relatives with AD and other dementias who can use the tailored Care ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
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