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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders

    SBC: ADVANCED LIQUID LOGIC            Topic: NICHD

    DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. It is primarily performed to detect disorders which lead to severe physical and mental disabilities. There is an increasing necessity to screen for a number of lysosomal storage disorders for which therapies are becoming available. T ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Development of an adipose-derived stem cell isolation matrix

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States. Autologous iliac crest bone graft continues to be the gold standard, because it provides essential elements for bone formation: progenitor cells, an osteoconductive matrix, and osteoinductive molecules. However, iliac crest harvest is associated with a significant numbe ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Delivery of Adipose Derived Stem Cells for Healing Surgical Hernia Repairs

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. Of these surgeries, 100,000 are for incisional or visceral herniarepairs, which cost 1.7B annually and have a recurrence rate that can be up to 60%. The incorporation of biocompatible mesh to strengthen the ab ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Melanocortin Ligands in Disease Cachexia

    SBC: TENSIVE CONTROLS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Cachexia-anorexia syndrome is a life-threatening aspect to many diseases, in particular many forms of cancer or therapies for cancer. The obvious symptoms of this disease include lack of appetite, and a loss of lean body mass disproportionate to the reduction in caloric intake. However, the less obvious effects include multi-organ failure, due to high metabolic ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Bioactive Peptide Coatings for Synthetic Bone Grafts

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Back pain is one of the leading reasons for physician visits in the United States and in many cases requires surgical intervention. In the United States, there are over 500,000 spinal fusion surgeries every year, and the frequency of these surgeries is projected to grow 6% per year. The gold standard for bone graft in spinal fusion is autograft from the iliac c ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Web-Based Dissemination Tool for Community Mental Health (WDT-C)

    SBC: 3-C Institute for Social Development, Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): Over the past several decades, a large number of mental health (MH) practices and interventions have been rigorously tested through randomized control trials and shown efficacious. However, despite availability, evidence-based interventions (EBIs) are rarely adopted in everyday practice within community MH service settings. Further, even when adopted, MH EBIs a ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Computerized Stage-Matched Intervention for Juvenile Offenders

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    DESCRIPTION (provided by applicant): Juvenile crime imposes enormous costs on victims, on society, and on juvenile offenders themselves. However, research assessing the efficacy of interventions for young offenders show, on average, only small effects on recidivism, substance abuse, and other behavioral outcomes. A major problem with existing interventions is that they tend to neglect individual d ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Ultra Wide Bandwidth High Dynamic Range Digital ISR Receivers for the submarine force

    SBC: SYSTEMS ENGINEERING ASSOCIATES CORPORATION            Topic: N101059

    This effort to improve the capabilities of the ESM system will increase the reliability and reduce lifecycle support costs of the Radar Wideband (RWB) subsystem on submarines. Analog to digital converter (A/D) based digital receivers will be applied to yield improvements in Radar signal acquisition and processing. In-phase and Quadrature (I/Q) data streams will be created from which intra pulse mo ...

    SBIR Phase II 2012 Department of DefenseNavy
  9. Peptide conjugation for Co-Delivery of Growth Factors and Stem Cells

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Autologous stem cells and growth factors provide valuable therapies for a variety of indications. When stem cells and growth factors are co-delivered, they produce a greater therapeutic effect than delivery of either stem cells or growth factors alone. However, the use of growth factors in the clinic is limited by the challenges of retaining the proteins at th ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. EpiVax Phase II SBIR: Preclinical studies of Tregitope Delivery and Mechanism of

    SBC: EPIVAX, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The goal of this Phase II project is to advance the development of novel tolerance-inducing peptides (Tregitopes) to prevent and/or treat Type 1 diabetes (T1D) by optimizing the clinical delivery vehicle and treatment protocol, and by identifying correlates of efficacy in preparation for Phase 1 clinical trials. More than 13,000 children in the U.S. are diagnos ...

    SBIR Phase II 2012 Department of Health and Human Services

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