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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel Biomarkers for Early Detection of Aspergillosis


    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients. The number of patients at risk for developing IA is steadily increasing due to advances in medicine. Early and accurate diagnosis of IA is critical to patient outcome, yet is exceedingly difficult due to the lack of sp ...

    STTR Phase I 2012 Department of Health and Human Services
  2. CMV Therapeutic Vaccine for the Treatment of Glioblastoma

    SBC: Annias Immunotherapeutics, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Recently, temozolomide (TMZ), a myelosuppressive alkylating chemotherapy, has shown a benefit in patients with glioblastoma multiformes (GBM), but median survival is still less than 15 months. Moreover, these conventional chemotherapies lack specificity and result in incapacitating damage to surrounding normal brain and systemic tissues. Immunotherapy may provi ...

    STTR Phase I 2012 Department of Health and Human Services
  3. A Quantitative Optical Sensor to Monitor Pre-Clinical Tumor Vascular Physiology

    SBC: Zenalux Biomedical, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Angiogenesis and hypoxia can significantly influence the efficacy of therapy and the behavior of surviving tumor cells. This important fact is supported by a vast amount of literature on pre-clinical models and clinical studies. There is growing demand for technologies to measure tumor hypoxia and angiogenesis temporally and spatially in vivo to enable advance ...

    STTR Phase I 2012 Department of Health and Human Services
  4. Novel SET Antagonists for the Treatment of Chronic Myelogenous Leukemia


    DESCRIPTION (provided by applicant): Chronic Myelogenous Leukemia (CML) affects nearly 14,000 patients worldwide and is a disorder of the pluripotent hematopoietic stem cells with two distinct phases. The protracted myelopoliferative chronic phase is followed by a rapidly fatal blast crisis. In CML, a chromosomal translocation leads to production of the Philadelphia Chromosome (Ph1) in which the ...

    STTR Phase I 2012 Department of Health and Human Services
  5. Development of a Novel Class for Opioid Drugs

    SBC: ALGYNOMICS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): The mu-opioid receptor (MOR) is the primary target for opioid analgesics. While opioids are the most frequently used and effective analgesics for the treatment of moderate to severe clinical pain, their prolonged use leads to reduced efficacy and a number of adverse side effects, including post dosing-induced hyperalgesia and analgesic tolerance. MOR induces an ...

    STTR Phase I 2012 Department of Health and Human Services
  6. Significant CT Radiation Dose Reduction with Equally Sloped Tomography


    DESCRIPTION (provided by applicant): CT has become a routine medical tool in diagnosis of diseases and visualization of critical interventional procedures. The number of CT examinations has significantly increased over the past two decades in the US, and reached approximately 72 million in 2007 alone [5,8]. According to the 2009 report from the National Council on Radiation Protection and Measurem ...

    STTR Phase I 2012 Department of Health and Human Services
  7. Development of a novel method for inhibiting diabetic retinopathy


    DESCRIPTION (provided by applicant): The long-term objective of the proposed study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy. Insulin-like growth factor-I (IGF-I) has been implicated in both endothelial dysfunction as well as the proliferative phase of the disease. However directly inhibiting the IGF-I receptor may be lead to neurotoxicity. Following ...

    STTR Phase I 2012 Department of Health and Human Services
  8. External Glaucoma Drainage Device

    SBC: CAMRAS VISION, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Glaucoma is one of the leading causes of blindness in the world affecting 67 million people. Reduction of intraocular pressure (IOP) is the only proven treatment for delaying the progression of vision loss caused by glaucoma. The current surgical options for IOP lowering are unpredictable and suboptimal in terms of success rate. One of the primary reasons for s ...

    STTR Phase I 2012 Department of Health and Human Services
  9. Using combinatorial control to improve transgene expression specificity in plants


    DESCRIPTION (provided by applicant): It is currently estimated that 15% of the world's population is undernourished and 5 million childhood deaths a year are attributable to malnutrition. The ability to feed the world in the future will be even more difficult due to population growth, climate change, water scarcity, and competition for land. It is widely recognized that advances in agricultu ...

    STTR Phase I 2012 Department of Health and Human Services
  10. Extended NeuroAmides: Novel Antiepileptic Drug Candidates

    SBC: NeuroGate Therapeutics, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Epilepsy is a set of disorders that result from neuronal hyperexcitability and hypersynchronous neuronal firing. Epilepsy remains a major widespread neurological concern. Current medications do not meet the health needsof 30% of epilepsy patients, and approximately 40% of patients experience serious side effects. So, the need for novel, more effective therapies ...

    STTR Phase I 2012 Department of Health and Human Services

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