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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of an Anti-P-selectin Antibody for the Treatment of Sickle Cell Disea

    SBC: SELEXYS PHARMACEUTICALS CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Selexys Pharmaceuticals is developing a humanized monoclonal antibody drug called SelG1 directed against P-selectin for the treatment of vasoocclusive crisis in patients with sickle cell disease. The ultimate goal of this Phase IIB proposal is to further advance SelG1 into Phase II/III safety and efficacy trials to support of regulatory filings for FDA approval ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an oral therapeutic to mimic the anti-diabetic effects of gastric bypass surgery

    SBC: BIOKIER, INC.            Topic: 200

    SUMMARY Glucose homeostasis and food intake are both regulated by gut hormones secreted from enteroendocrine L- cells in the lower gut following stimulation by nutrients. This process is impaired in diabetes but is restored with delivery of dietary nutrients such as amino acids and fatty acids to the lower gut, such as after gastric bypass surgery and during fermentation of carbohydrates in the co ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. New Class of Bright, Sharp, Tunable Near-Infrared Fluorophores for Flow Cytometry

    SBC: Nirvana Sciences, Inc.            Topic: NIAID

    Abstract Polychromatic flow cytometry (FC) is one of the most powerful analytical techniques routinely used by both basic research and clinical diagnostics laboratories for the immunological categorization of cells. Dyes used for FC typically exhibit broad fluorescent emission bands with full-width-at-half-maximum (fwhm) values of 50–80 nm. This limits the maximum number of dyes, and thus the nu ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders

    SBC: ADVANCED LIQUID LOGIC            Topic: NICHD

    DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. It is primarily performed to detect disorders which lead to severe physical and mental disabilities. There is an increasing necessity to screen for a number of lysosomal storage disorders for which therapies are becoming available. T ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Adaptive Optics System for Meter-Class Space Surveillance Telescopes

    SBC: HART SCIENTIFIC CONSULTING INTERNATIONAL L.L.C.            Topic: AF171023

    The adaptive optics system we propose is designed to operate at the Coudé focus of a 1-m space surveillance telescope at the Starfire Optical Range. The system is to have correction capability to D/r0 = 20 and Greenwood frequency fG = 160 Hz. The mission requirements driving the design relate to the search for closely spaced objects (CSO) around high-value assets in geosynchronous Earth orbit. ...

    SBIR Phase II 2019 Department of DefenseAir Force
  6. Development of a New Carbohydrate-based Anticoagulant Drug

    SBC: GLYCAN THERAPEUTICS CORPORATION            Topic: NHLBI

    Low molecular weight heparins (LMWHs) are partially depolymerized natural products of heparin, which are isolated from porcine intestine. A worldwide distribution of contaminated heparin in 2007 was associated with 85 deaths in the US. This crisis revealed the vulnerability of the LMWH supply chain. LMWHs are complex mixtures, having average molecular masses of 3500-6000 Daltons, corresponding to ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Low Signature Optical Guidance of Low Collateral Munitions

    SBC: CORVID TECHNOLOGIES, LLC            Topic: SOCOM061008

    At present, there are no solutions for equipping Class 1 and 2 unmanned aerial system (UAS) platforms with weapons systems that provide the capability for opportunistic engagement of high value targets (HVT). Munitions deployed on larger UAS, and other fixed-wing SOCOM assets, greatly exceed the payload capacity of Class 1 and 2 UAS assets currently in use for intelligence, surveillance, and recon ...

    SBIR Phase II 2019 Department of DefenseSpecial Operations Command
  8. Ground Based Weaponized Unmanned Aircraft System

    SBC: Brock Technologies, Inc.            Topic: AF083006

    ABSTRACT: The Military has a critical need for a tactical weapon to engage soft, fixed targets in remote areas. A system is needed to operate semi-autonomously to destroy or disable nearby targets in support of base defense and a variety of other soft target applications within a 30km range. Brock Technologies Kinetic Fan Tactical Missile (KFTM) developed under this Phase II effort will address t ...

    SBIR Phase II 2012 Department of DefenseAir Force
  9. Development of an adipose-derived stem cell isolation matrix

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States. Autologous iliac crest bone graft continues to be the gold standard, because it provides essential elements for bone formation: progenitor cells, an osteoconductive matrix, and osteoinductive molecules. However, iliac crest harvest is associated with a significant numbe ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
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