Award Data

PROJECT SUMMARY / ABSTRACTThe objective of this Phase II proposal is to further develop a novel device for ocular anesthesia based on thermo-electric cooling. Intravitreal injection therapy (IVT) is one of the most commonly performed procedures in all of medicine, with approximately 7 million injections in the USA in 2016. Ocular anesthesia is required, both for patient safety and for tolerability ...

Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

To address the DHS need to rapidly detect radio interference of critical radio frequency (RF) communications channels utilized by first responders, Physical Optics Corporation (POC) proposes to develop a new Miniature Intelligent Spectral Analyzer (MISCAN) device based on a combination of commercial off-the-shelf (COTS) electronic components in a custom software-defined configuration along with in ...

As Internet of Things (IoT) and mobile devices become increasingly popular and widely used, the security of the firmware running on these devices is paramount.However, due to the lack of an efficient and scalable analysis framework, combined with the increasing pressure to get products to market as quickly as possible, the software running on these devices is never properly checked for security vu ...

DHS has an unmet need for measuring ultra-high-intensity, near-field blast overpressure caused by internal blast within a commercial aircraft explosive threat environment in order to facilitate characterization of blast effects to commercial aircraft structures.The goal of this DHS SBIR OATS project is to deliver advanced thin, flexible, conformable, multi-sensing-point film sensor technology for ...

A majority of U.S. adults own a cell phone and are inclined to use it in emergency situations to call for assistance. Unfortunately, in areas where the density of cell towers is low, such as in rural and off-shore environments, the ability of the wireless network to geolocate the origin of the wireless signal is poor to non-existent. Under the proposed effort, Toyon Research Corporation will devel ...

To address the Department of Homeland Security (DHS) need for a cell phone location finder for maritime and remote search and rescue (SAR), Physical Optics Corporation (POC) proposes to develop a new REmote Phone Locator for Improved Emergency Rescue (REPLIER). REPLIER leverages novel techniques recently developed at POC to extend the range of cellular communications and integrate commercial cellu ...

Advances in clinical research have yielded many evidence-based guidelines to help clinicians provide the right care for the right patient at the right time; however, studies suggest that nearly half the time, that care does not reach the patient. Clinical decision support (CDS) is an information technology-enabled method to identify missed opportunities and optimize care. This proposal seeks to sy ...

The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...