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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The purpose of this contract is to develop imprinted polymer resins for the purification of HIV envelope vaccine candidates

    SBC: Zymeron Corporation            Topic: NIAID

    There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Augmented Commercial Radio for Navigation (ACORN)

    SBC: Setter Research, Inc.            Topic: HSB0181004

    The Global Positioning System (GPS) and other global navigation satellite systems (GNSS) have become critical elements of diverse activities including safe and efficient ground and air transportation, manufacturing, power generation, financial transactions, farming, cellular communications, first responder operations, law enforcement, consumer activities, all in addition to military operations for ...

    SBIR Phase I 2018 Department of Homeland Security
  7. Promoting Responsible Drinking: An Internet-based, Interactive Computer Tailored Intervention

    SBC: Pro-Change Behavior Systems Inc            Topic: NIAAA

    DESCRIPTION provided by applicant Excessive alcohol use is associated with a range of serious and costly health social and economic consequences at the individual and societal level This program of research serves as a venue by which to produce and test an innovative science based and cost effective means to intervene in a private convenient and individualized way with employed adults wh ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  8. COTS MMW Radar for Tracking Persons within a Security Perimeter

    SBC: PSQUAREDT LLC            Topic: HSB0121005

    The implications of the proposed investigations are that radar systems already implemented for the automotive industry can be exploited, adapted and optimized for this application. These radar systems are inexpensive, of small size, employ advanced processing techniques which allow the tracking of threat targets, transmit low average power (10 milliwatts) and are proven to be people safe. We will ...

    SBIR Phase I 2012 Department of Homeland Security
  9. A Novel Fractionation and Concentration System for Improved Biological Detection

    SBC: InnovaPrep, LLC            Topic: HSB0111002

    Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist and pandemic events. Rapid bioaerosol detection systems have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a major deficiency. Three significant issues are (a) a lack of an interface between large environmental samples and sample p ...

    SBIR Phase II 2012 Department of Homeland Security

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