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THIS PROJECT OUTLINES A RELIABILITY AND MAINTAINABILITY KNOWLEDGE BASE AND THE HYPERTEXT INTERFACE REQUIRED TO TRANSPORT THIS DATA INTO COMPUTER-AIDED DESIGN (CAD) ENVIRONMENTS. THE PRIMARY FOCUS OF THE PROPOSAL IS THE DEVELOPMENT OF THE FOUNDATION FOR AN ENGINEERING RELIABILITY AND MAINTAINABILITY INFORMATION PRESENTATION SYSTEM TO SUPPORT ELECTRONIC CIRCUIT AND SYSTEMS DESIGN ENGINEERS IN A CAD ...

A NEW GENERATION OF ENGINEERING AND MANUFACTURING AUTOMATION DESIGNTOOLS ARE NOW EMERGING AS A RESULT OF THE PIONEERING WORK THAT HAS BEEN DONE IN OBJECTORIENTED PROGRAMMING TECHNOLOGY. UNLIKE CONVENTIONAL PROCEDURAL LANGUAGE APPROACHES, THE OBJECT-ORIENTED PROGRAMMING APPROACH ALLOWS DATA STRUCTURES AND PROCEDURES TO BE DEFINED FOR GENERIC CLASSES OF OBJECTS. SYSTEM PERFORMANCE, RNA, AND COST DAT ...

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NUMEROUS ANCHORAGE-DEPENDENT CELLS SHOW IMPROVED ATTACHMENT,IMPROVED GROWTH, AND REDUCED SERUM REQUIREMENTS WHEN CULTURED ON SURFACES COATED WITH EXTRACELLULAR MATRIX COMPONENTS (ECM'S). THE MAJOR ACTIVE PROTEINS IN ECM'S ARE FIBRONECTIN, LAMININ, AND TYPE IV COLLAGEN. MOST OF THE CELL ADHESION ACTIVITIES OF THESE PROTEINS RESIDE IN TWO PEPTIDE SEGMENTS (RGD AND YIGSR), AND BOTH PEPTIDES ARE ACTIV ...

PROSTHETIC DEVICES ARE ROUTINELY IMPLANTED IN PATIENTS; HOWEVER, AN ESTIMATED 850,000 CASES OF IMPLANTATION INFECTIONS OCCUR IN THE UNITED STATES EACH YEAR. THE INFECTIOUS ORGANISMS ARE MOST LIKELY TO BE INTRODUCED AT THETIME OF SURGERY. CURRENTLY, INFECTIONS RESULTING FROM IMPLANTATION ARE TREATED AS THEY OCCUR; HOWEVER, PREVENTION IS THE MOST PROMISING APPROACH TO DECREASING DEVICE-ASSOCIATED SE ...

THE USE OF TOBACCO PRODUCTS WITH ALL ITS DELETERIOUS EFFECTSUPON THE GENERAL HEALTH OF OUR POPULACE WAS AND STILL IS A MAJOR HEALTH PROBLEM. ALTHOUGH THE NUMBER OF SMOKERS HAS DECREASED OVER THE LAST DECADE, SMOKERS ARE SMOKING MORE CIGARETTES AND ADOLESCENTS ARE USING NOT ONLY CIGARETTES BUTALSO LARGE QUANTITIES OF SMOKELESS TOBACCO. THERE IS ALSO CONCERN WITH REGARD TO THE EFFECTS OF PASSIVE SMO ...

THE IMMOBILIZATION OF BIOLOGICALLY ACTIVE MOLECULES ON SUPPORT MATRICES HAS MANY APPLICATIONS IN BIOTECHNOLOGY. PASSIVE ADSORPTION OF BIOMOLECULES (BOTH HYDROPHOBIC AND IONIC) TO POLYMERIC MATRICES IS THE LEAST COMPLICATED METHOD OF IMMOBILIZATION; HOWEVER, MANY BIOCHEMICALS DO NOT ADSORB WELL TO PLASTIC POLYMER SURFACES. IN PARTICULAR, CARBOHYDRATES ARE OFTEN DIFFICULT TO ADSORB WITH A SUFFICIENT ...