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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Pulse Pileup Recovery for Energy Dispersive Spectroscopy

    SBC: 4pi Analysis, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1993 Department of Health and Human Services
  2. IMMOBILIZED OXIDO-REDUCTASE ENZYMES IN ORGANIC SYNTHESIS

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1993 Department of Health and Human Services
  3. IMMOBILIZED OXIDO-REDUCTASE ENZYMES IN ORGANIC SYNTHESIS

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase II 1993 Department of Health and Human Services
  4. DRUG CHALLENGE ASSAY FOR USE IN THROMBOLYTIC THERAPY

    SBC: Biotherm, Inc.            Topic: N/A

    A TEST SYSTEM FOR RAPID SCREENING OF PATIENTS PRIOR TO INITIATION OF THROMBOLYTIC THERAPY WILL BE DEVELOPED. THIS SYSTEM WILL BE BASED ON A NOVEL DRY REAGENT ASSAY TECHNOLOGY WHICH RECENTLY HAS BEEN APPLIED SUCCESSFULLY TO PT AND ACTIVATED PTT TESTS. INTRODUCTION OF A RAPID CONVENIENT TEST OF PATIENT (OR CLOT) LYTIC POTENTIAL FOR USE ON A DECENTRALIZED BASIS COULD PROVIDE EARLY INDICATION OF LIKEL ...

    SBIR Phase II 1993 Department of Health and Human Services
  5. NUCLEOSIDE PHOSPHATE ANALOGUES WITH BORONATED PHOSPHATES

    SBC: BORON BIOLOGICALS, INC.            Topic: N/A

    USE OF NUCLEOSIDE PHOSPHATES AS ANTITUMOR AND ANTIVIRAL AGENTS HAS BEEN LIMITED BY THEIR INABILITY TO PENETRATE CELL MEMBRANES AS WELL AS THEIR HIGH SUSCEPTIBILITY TO ENZYMES SUCH AS PHOSPHATASES, NUCLEOTIDASES, ETC. MODIFICATION OF THE PHOSPHATE GROUP (BY REPLACING ONE OF THE NONBRIDGING OXYGENS WITH A BORANE GROUP) MAY PROVIDE BOTH THE MEMBRANE PERMEABILITY TO THESE COMPOUNDS AND THE STABILITY ( ...

    SBIR Phase II 1993 Department of Health and Human Services
  6. Amine-Boranes as New Topoisomerase II Inhibitors

    SBC: BORON BIOLOGICALS, INC.            Topic: N/A

    The main objective of the research is to develop a new class of topoisomerase II (Topo II) inhibitors as antineoplastic agents. In preliminary studies, heterocyclic amine-carboxyboranes have been shown to possess cytotoxic activity against a number of murine and human tumor tissue culture lines, e. g. P388, L1210, Tmolt3, HeLa-S3, lung bronchogenic, KB nasopharynx, glioma, and osteosarcoma. These ...

    SBIR Phase I 1993 Department of Health and Human Services
  7. Boronated Nucleoside Bases

    SBC: BORON BIOLOGICALS, INC.            Topic: N/A

    We will design and synthesize novel nucleic acid base derivatives containing cyanoborane group attached to a pyridine-type nitrogen atom of the purine or the pyrimidine cycle. The cyanoboronated bases may be designed to be more membrane soluble than the respective 2'- deoxyribonucleosides of known cytotoxic activities. In living organisms, these base derivatives may be converted to the 5'-nucleoti ...

    SBIR Phase I 1993 Department of Health and Human Services
  8. Boronic Acid Analogs of Nucleoside-5'-Phosphates

    SBC: BORON BIOLOGICALS, INC.            Topic: N/A

    A major problem with the use of nucleoside phosphates as antiviral and antitumor drugs has been their inability to penetrate cell membranes. Additionally, nucleoside phosphates are susceptible to phosphatases and nucleases, which reduce their in vivo life time. Replacement of the charged phosphate group with uncharged boron containing moieties should not only enhance their cell permeability, but t ...

    SBIR Phase I 1993 Department of Health and Human Services
  9. IMPROVED DETECTION AND CLASSIFICATION FOR SHALLOW-WATER ASW

    SBC: Carolinian Systems Research            Topic: N/A

    A new approach to signal detection and classification is applied to the problem of ASW and torpedo defense for shallow-water environments. The approach is particularly appropriate for applications where the statistics of the signal and the noise are unknown and highly variable. The primary goal is a significant improvement in the detection capability of sonar for ASW in coastal shallow water envir ...

    SBIR Phase I 1993 Department of DefenseNavy
  10. NICKEL COATING OF ALUMINUM ALLOYS

    SBC: Covofinish Co., Inc.            Topic: N/A

    An investigation of nickel coating processes to provide corrosion protection for 6061-T6 aluminum alloy in a marine environment is proposed. The effects of aluminum preparation and pretreatment steps will be investigated. Additionally, strategies which utilize multiple layers of nickel of different compositions will also be explored.

    SBIR Phase I 1993 Department of DefenseNavy

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