Award Data

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects - elderly, diabetics, and stroke sufferers - a notable increase in tactile and proprioceptive sensitivity is seen whe ...

Stochastic resonance (SR), a counterintuitive phenomenon in which slight amounts of environmental noise actually increase the discernability of signals or stimuli, produces a demonstrable effect in human sensory cells. In both healthy young and clinical subjects- elderly, diabetics, and stroke sufferers-a significant increase in tactile and proprioceptive sensitivity is noted when electrical or me ...

Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects-elderly, diabetics, and stroke sufferers-a notable increase in tactile and proprioceptive sensitivity is seen when el ...

Human Papilloma Virus (HPV) types 16 and 18 are detected in roughly 70% of all invasive cervical tumors. Among cytologically normal women, detection of HPV infection by PCR has been shown to increase the subsequent risk of cervical cytologic abnormalities by 12 fold, suggesting that effective vaccines (preventive/therapeutic) for HPV infection would be a useful medical advance in the battle agains ...

DESCRIPTION (provided by applicant): West Nile virus (WNV) is a flavivirus commonly found in Africa, West Asia, and the Middle East. The virus was introduced into the United States in 1999. Case-fatality rates during the 1999-2000 U.S. epidemics ranged from 3 percent to 15 percent and were highest in the elderly. The virus is expected to over-winter during ...

The goal of this project is to develop a more powerful and robust system for the sequencing and analysis of DNA by hybridization to microarrays. Our conceptually novel approach is based on a new probe design and sequence reconstruction algorithm which has been demonstrated by computational modeling to provide higher information density on a DNA hybridization chip. The Human Genome Project is provi ...

A variety of effective interventions exist for people who seek help for depression. However, there is a lack of effective interventions for individuals who do not seek help or follow through with treatment referrals. We propose to fill this gap in services by developing and testing a Transtheoretical Model-based intervention that will be delivered proactively, on a population basis, to primary car ...