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PROJECT SUMMARY We propose to build a cloud based integrated solution for scalablecustomizableprivacy preservingand interactive antibody repertoire analysisImmune repertoire sequencingIR seqhas become a useful tool in both basic research and clinical settingsAs the heart of the adaptive immunity to infection and many vaccinesthe abundance and diversity composition of the B cell receptorBCRand its ...

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Project Summary Abstract PTIis a novel small molecule AD therapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorTLRHenceby restoring FLNAa ...

Abstract Neuroene Therapeutics is a biotech company established to develop and commercialize safe effective therapies for epilepsyinpeople develop epilepsy in their lifetimehowever the currently available anti epileptic drugsAEDshave several issues and liabilities that leave unmet market needssuch asnot controlling seizures forof patients with epilepsycurrent AEDs only treat the symptoms of epilep ...

PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

Abstract Critical to the future progress of cancer immunotherapies is the discovery and tracking of T cells specific for cancer cells but not normal tissuesNeo antigen derived from mutations are a group of attractive antigens for cancer immunotherapyBecause they are mutated variants of self antigensthey are immunologically considered as foreign antigens and are not part of the self antigensThusthe ...

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Severe loss of vision occurs due to age-related macular degeneration (AMD) and approximately 15 million people in the US have some form of AMD, which is expected to double by 2050. Most of the current clinical treatments are primarily focused on slowing down the progression of the disease, as there is neither a cure that can stop the degeneration nor a therapy, other than retinal prostheses, that ...

A MINIATURE ARTIFICIAL KIDNEY WHICH IS WORN ON THE WRIST LIKE A BRACELET FOR AS LONG AS A WEEK IS BEING DESIGNED AND TESTED. ONLY SMALL SNAP-ON CARTRIDGES HAVE TO BE CHANGED EVERY FEW HOURS. IN PHASE I, THE IDEA THAT A SMALL DEVICE USED CONSTANTLY IS AS EFFICIENT AS A LARGE MACHINE USED THREE TIMES A WEEK IS BEING PROVED IN THE LABORATORY. ALSO,MANY SMALL SORBENT CARTRIDGES ARE BEING USED IN THE E ...

Advancements in precise genetic manipulation have helped biologists to identify new drug targets and in vivo disease mechanisms using small animal modelssuch as CelegansHuman diseases pathophysiologies are reproduced in Celegans expressing human disease genes inside the animalGreat opportunities are provided by the recent surge is genetic tools for animal modelsbut the lack of high content screeni ...