Award Data

The proposed Phase II SBIR program is dedicated to the creation and testing of a multispecific DNA biowarfare sensor based on ultrathin oligonucleotide-modified conducting polymer films. Based on the reagent-free sensor prototype developed in Phase I, wh

OmniSite proposes to continue Phase I effort to develop aptamer-based assays to anthrax spores and SEB for detection instruments based on ECL, FP, and FRET formats. OmniSite will compare the different assay formats to determine which of thesedemonstrates the most sensitivity and specificity, as well as being robust, cost effective, and facile. Performance characteristics of the most sensitive ...

Besides performing a thorough statistical analysis of the government furnished data sets to determine the features and metrics for spectral unmixing, Intelligent Automation, Inc. and Prof. C. Chang of University of Maryland at Baltimore County also proposean innovative approach to detect and classify chemical and biological agents. There are two major steps. First, we propose to apply a recently d ...

During the anthrax attacks in 2001, investigators had difficulty in differentiating the strains apart because B. anthracis has a low level of genetic variability. This event demonstrated the need for rapid and precise molecular subtyping technologies. Lynntech proposes to develop an ultra-sensitive quantum dots-based molecular beacon fluorogenic reporter system to identify the presence of specif ...

While the phenomenon of suspended animation has not been widely studied in humans, there are many anecdotal and medically verified examples of humans being in a state that is comparable to suspended animation when they have been accidentally nearly frozenfor short periods of time. There could be many advantages to inducing suspended animation or hypometabolism in humans such as extending survival ...

The threat of chemical warfare agents used against our military is as great as it ever has been. The U.S. Naval forces present large targets for terrorist type activities at all parts of the globe. There are many types of quick detection strategies, suchas M8/M9 paper and Chemical Agent Monitors, which can screen liquid and powder forms of chemical agent dispersal, respectively. However, the ne ...

A miniature, transportable filter system is required for warfighters when traditional resupply is unavailable. The desired technology would remove both chemical and biological agents. A device that integrates sensing capability to actuate the purification system is also desired. We developed a non-woven filter using a nano alumina fiber only 2 nanometers in diameter. It is capable of > 99.9999 ...

Chesapeake PERL is a contract manufacturing company using the baculovirus expression system for mass production of proteins in lepidopterous insect larvae. PERL's automated in-line insect mass rearing and inoculation systems enables the production oflarge quantities of complex, biologically fully functional proteins. The baculovirus expression system as developed in the eighties and nineties is ...

Suspended or reduced animation of brain and heart tissues during battle-field injury or during critical-care trauma may result in a significant protection from organ damage, systemic shock, and pain and may provide a prolonged window of opportunity fortreatment. Suspended or reduced animation of brain and heart tissues may be achieved by a complete suspension or suppression of neural activities ( ...

Foodborne pathogen detection has always been faced with volume and matrix problems, i.e., low numbers of viral or bacterial pathogens in a large volume of solid or liquid foods that are still potentially infectious. Despite sensitive techniques such as PCR and immunomagnetic-electrochemiluminescence (IM-ECL), there still exists a need to concentrate and semi-purify pathogens from large (liter) vo ...