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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Aptamer Enhanced Biorecognition Reagent System

    SBC: OMNISITE BIODIAGNOSTICS, INC.            Topic: N/A

    OmniSite proposes to continue Phase I effort to develop aptamer-based assays to anthrax spores and SEB for detection instruments based on ECL, FP, and FRET formats. OmniSite will compare the different assay formats to determine which of thesedemonstrates the most sensitivity and specificity, as well as being robust, cost effective, and facile. Performance characteristics of the most sensitive ...

    SBIR Phase II 2003 Department of DefenseOffice for Chemical and Biological Defense
  2. A Novel Approach for Spectral Unmixing and Classification of Chemical and Biological Agents

    SBC: Intelligent Automation, Inc.            Topic: N/A

    Besides performing a thorough statistical analysis of the government furnished data sets to determine the features and metrics for spectral unmixing, Intelligent Automation, Inc. and Prof. C. Chang of University of Maryland at Baltimore County also proposean innovative approach to detect and classify chemical and biological agents. There are two major steps. First, we propose to apply a recently d ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  3. Portable System for Sample Preparation and Differentiation of Pathogens at Strain Level

    SBC: Lynntech Inc.            Topic: CBD04107

    During the anthrax attacks in 2001, investigators had difficulty in differentiating the strains apart because B. anthracis has a low level of genetic variability. This event demonstrated the need for rapid and precise molecular subtyping technologies. Lynntech proposes to develop an ultra-sensitive quantum dots-based molecular beacon fluorogenic reporter system to identify the presence of specif ...

    SBIR Phase I 2004 Department of DefenseOffice for Chemical and Biological Defense
  4. RNAi screening for Identification of Compounds to Induce Suspended Animation or Hypometabolism

    SBC: AGAVE BIOSYSTEMS INC.            Topic: N/A

    While the phenomenon of suspended animation has not been widely studied in humans, there are many anecdotal and medically verified examples of humans being in a state that is comparable to suspended animation when they have been accidentally nearly frozenfor short periods of time. There could be many advantages to inducing suspended animation or hypometabolism in humans such as extending survival ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  5. Polyoxometalate Nanoparticles as Reversible and Selective Surface Contamination Monitors

    SBC: Lynntech Inc.            Topic: N/A

    The threat of chemical warfare agents used against our military is as great as it ever has been. The U.S. Naval forces present large targets for terrorist type activities at all parts of the globe. There are many types of quick detection strategies, suchas M8/M9 paper and Chemical Agent Monitors, which can screen liquid and powder forms of chemical agent dispersal, respectively. However, the ne ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  6. Amplification of Molecular Signal Using Highly Stabilized Acoustic Wave Devices

    SBC: TPL, INC.            Topic: N/A

    U.S. forces require rapid, early and accurate pathogen detection systems designed for use in extreme combat situations. Numerous options to deliver weaponized pathogens drives the necessity for U.S. forces to have technology to detect infectious pathogens.TPL has conceived a unique methodology for amplifying the presence of a pathogen without multiplying physical number of pathogens. TPL proposes ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  7. Improved Protein Manufacturing in Insect Expression Systems

    SBC: Chesapeake Perl, Inc.            Topic: N/A

    Chesapeake PERL is a contract manufacturing company using the baculovirus expression system for mass production of proteins in lepidopterous insect larvae. PERL's automated in-line insect mass rearing and inoculation systems enables the production oflarge quantities of complex, biologically fully functional proteins. The baculovirus expression system as developed in the eighties and nineties is ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  8. Amplification of Molecular Signals

    SBC: MesoSystems Technology, Inc.            Topic: N/A

    The goal of the proposed research is to develop a highly sensitive and specific amplification system that can be coupled to any pathogen detection and quantification unit for sensitive real-time detection of biological warfare agents. The system is builtaround a dual-enzyme substrate-recycling electrochemical amplification system coupled to an immunoassay detection technology that has already been ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  9. Identification of Compounds to Induce Suspended Animation or Hypometabolism

    SBC: Neuralstem, Inc.            Topic: N/A

    Suspended or reduced animation of brain and heart tissues during battle-field injury or during critical-care trauma may result in a significant protection from organ damage, systemic shock, and pain and may provide a prolonged window of opportunity fortreatment. Suspended or reduced animation of brain and heart tissues may be achieved by a complete suspension or suppression of neural activities ( ...

    SBIR Phase I 2003 Department of DefenseOffice for Chemical and Biological Defense
  10. Magnetic Concentrator & Cartridge System to Enhance Food Safety

    SBC: Operational Techologies Corporation            Topic: CBD04108

    Foodborne pathogen detection has always been faced with volume and matrix problems, i.e., low numbers of viral or bacterial pathogens in a large volume of solid or liquid foods that are still potentially infectious. Despite sensitive techniques such as PCR and immunomagnetic-electrochemiluminescence (IM-ECL), there still exists a need to concentrate and semi-purify pathogens from large (liter) vo ...

    SBIR Phase I 2004 Department of DefenseOffice for Chemical and Biological Defense

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