Award Data

DESCRIPTION (provided by applicant): The ability to culture human embryonic stem cells generated a great deal of excitement about their vast potential for treating a variety of human diseases such as diabetes, heart disease, neurological, retinal and skin disorders to name a few. Unlike adult stem cells, embryonic stem cells have indefinite growth potential and the potential to develop into any t ...

DESCRIPTION (provided by applicant): The overall goal of this project is to design and build cameras that can efficiently detect and image isotopes that have gamma rays with energies that are typically beyond those effectively accessible with conventional cameras. There are no nuclear medicine clinical cameras, today, that combine high efficiency with the ability to image high-energy gamma rays. ...

DESCRIPTION (provided by applicant): In this project our goal is to develop and commercialize a very low cost microarray chip fabrication technology to reduce the cost by as much as a factor of ten and enable the use of microarrays by groups who can not afford the current generation of microarrays. Our technology combines the standard acid labile DMT protection group containing nucleophosphoramidi ...

DESCRIPTION (provided by applicant): Many Americans suffer from ocular diseases which require application of topical therapeutic agents. These diseases range from bacterial conjunctivitis to intraocular inflammation. Keratoconjunctivitis sicca (dry eye) affects nearly 30 million people. Glaucoma affects 2 to 3 million Americans. Topical treatments exist but their ability to deliver drugs to the ey ...

DESCRIPTION (provided by applicant): The long-term objective of this application is to develop a wearable multi-sensor way finding device for the visually impaired that can function reliably both indoors and outdoors. The Phase I specific aims are to: 1) assemble and test a hardware platform that consists of a pocket-size computer and four sensors: a wireless signal receiver inside a wearable comp ...

DESCRIPTION (provided by applicant): Our aim is to develop an inexpensive and portable nanotechnology-based immunosensor and instrument platform for rapid detection of presence or exposure to bioterror agents in air, water, contaminated surfaces, forensic samples, food and body fluids through identification of protein toxins and microorganisms. The proposed approach employs single or multiple coni ...

DESCRIPTION (provided by applicant): The death rate due to respiratory disease has increased nearly 20% in the United States since 1979, surpassing virtually all other types of disease. Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30 and 70%. Current treatment is limited to extracorporeal membrane oxygenation (ECM ...

As reported by Internet security threat reports, Bot networks are becoming the focal point for cybercriminals. Milcord and the University of Wisconsin, responds to this challenge with our proposal ¿ a ¿Bayesian Activity Monitor for Botnet Defense¿ (BAM-BD). In this proposal, we will research, design, and develop a botnet detection and mitigation tool that automatically classifies botnet behavio ...

DESCRIPTION (provided by applicant): Project Summary: The laboratory mouse is an essential experimental resource for modern biomedical research. Scientists currently use hundreds of varieties and strains of mice, and generate over 10 million individual animals each year. Tens of millions of dollars of NIH funding annually support mouse model research, with millions directly allocated to the mainte ...

DESCRIPTION (provided by applicant): The increasing costs of therapy and the demonstrated benefits of improved treatment efficacy with early detection are important incentives to develop tumor diagnostic agents of greater specificity and sensitivity. Paramagnetic gadolinium complexes are widely used as MRI (magnetic resonance imaging) contrast agents to improve sensitivity and/or specificity duri ...