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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates

    SBC: MICROBRIGHTFIELD, LLC            Topic: 105

    Abstract This project aims to develop the 2P-ActivityScope™, a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection (SLAP2) two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski (Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA). The game-changing innovation in the 2P-Ac ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Computational techniques for gene engineering, such as codon optimization, use synonymous codon changes to increase protein production. Applications for these computational gene optimizations include recombinant protein drugs, nucleic acid therapies, and mRNA vaccines. Although codon optimization increases protein production in certain systems, synonymous changes to a gen ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. A synergistic in vitro-in silico model of the placental barrier for predicting fetal exposure and toxicity of xenobiotic compounds

    SBC: CFD RESEARCH CORPORATION            Topic: NICHD

    The placenta is one of the least understood organs of the human body. Acting as a barrier between mother and fetus, the placenta mediates transport of oxygen, nutrients, fetal waste products and other compounds present in maternal circulation. Full term placental explants are currently the most widely used models for assessing transport and barrier function. Unfortunately, these models are depende ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Next generation axonal quantification and classification using AI

    SBC: MICROBRIGHTFIELD, LLC            Topic: 101

    Abstract This Phase II project describes the commercial development of HyperAxon™, highly innovative software for performing automated segmentation, tracing, reconstruction and quantitative analysis of all axonal fibers (with and without signs of acute axonal injury) visible in two- and three-dimensional (2D and 3D) microscopy images of central nervous system (CNS) areas, even those with extreme ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Design of a bioactive mimetic of soluble klotho for the treatment of chronic kidney disease

    SBC: Alpha Young LLC            Topic: 400

    PROJECT SUMMARY Over 37 million individuals in the U.S. have chronic kidney disease (CKD) and are at high risk to die from cardiovascular complications. While great strides have been made to improve CKD care and dialysis access, minimal advances have been made in drug development to stall or reverse kidney damage and associated pathologies. Currently, therapeutic options to prevent cardiovascular ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy

    SBC: MICROBRIGHTFIELD, LLC            Topic: 101

    Abstract This project aims to develop and commercialize the Volumetric Calcium Imaging 2-Photon Activity Microscope, vCAm™, a revolutionary new 2-photon microscope based on a technological breakthrough called Light Beads Microscopy (LBM) that was recently developed by Dr. Alipasha Vaziri and co-workers (Lab. Neurotechnol. Biophys., Rockefeller Univ., New York, NY). The game-changing innovation i ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Harmony AI: Natural Language Processing Enabling Advanced Biomanufacturing

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Recombinant proteins have a wide range of applications, from pharmaceutical products, drug discovery, protein-based polymers for drug delivery, antibodies enzymes, and sustainable technologies such as textiles and vegan food production such as the impossible burger. Towards meeting these increased demands by replacing batch culture with continuous culture reduces overhead ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants

    SBC: ENDOMIMETICS LLC            Topic: NIAMS

    Osteoarthritis (OA) is a degenerative joint disease that affects over 32 million individuals in the United States, causing debilitating joint destruction and chronic joint pain, stiffness, and physical impairment. To restore and improve the patient’s quality of life, total knee arthroplasty (TKA) is the most common surgical intervention performed for OA to replace the compromised joint with arti ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD

    SBC: ALVEOLUS BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY - ResBiotic Inc. is developing its lead drug product, RB1000, a spray-dried powder com- prised of an inhaled biotherapeutic API for treatment of neutrophilic inflammation and disease progression in COPD patients. COPD is a chronic degenerative disease that is the fourth leading cause of death in the U.S., where it predominantly results from tobacco smoke exposure. Acute exacerbatio ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Patient Care Environment through Immersive Virtual Reality

    SBC: CFD RESEARCH CORPORATION            Topic: 20

    To develop an immersive VR environment where clinicians can interact with patients with rare diseases using virtual avatars.

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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