Award Data

DESCRIPTION (provided by applicant): The number of patients treated for antibiotics-resistant infections has increased drastically in recent years. What started as a problem primarily associated with hospital-acquired Enterococcus infections, has not only moved into the general community, but also grown to include a number of widespread and serious pathogens. Drug-resistant Streptococci, Staphyloc ...

DESCRIPTION (provided by applicant): Principal Investigator/Program Director (Last, First, Middle): Abstract We propose to design and deploy a handheld breath-based "personal" medication adherence monitoring system (MAMS) which will meet the criteria of the solicitation from the National Institute of Mental Health (NIMH) for "Development of information, instruments or methodologies to improve and/ ...

DESCRIPTION (provided by applicant): Background: Primary carcinoma of the lung is the leading cause of cancer death in the United States. A test that detects early-stage disease could potentially reduce the number of deaths. A breath test for volatile organic compounds (VOCs) was sensitive and specific for primary lung cancer in two multicenter clinical studies. A third multicenter study confirmed ...

DESCRIPTION (provided by applicant): Millions of children in the U.S. are at risk for learning to read well despite major advances in our understanding of the causes and cures for poor reading. In this Fast- Track proposal we propose to address this signif icant need and opportunity with a computer-based reading program that combines the power of one-on-one tutoring with the benefits of self-asses ...

DESCRIPTION (provided by applicant): Our goals in Phases I and II have been completed and showed the feasibility of our approach for assessing brain vascular autoregulatory responses to hypoxic stimuli. Frequency Domain Near-Infrared Spectroscopy offers the advantage of performing safe, non-invasive, transcranial, quantitative, real time measurements of cerebral hemodynamics and oxygenation. Our ...

DESCRIPTION (provided by applicant): The objective of this Phase I research is to demonstrate the feasibility of creating timed-bioabsorbable Pd-103 seeds for the treatment of prostate tumors. Timed- bioabsorbable seeds have the combined benefits of titanium seeds, high dose rate temporary seeds, external beam radiation and other treatment options. In addition, timed-bioabsorbable seeds potentiall ...

DESCRIPTION (provided by applicant): P2D, Inc. is developing a synthetic melatonin analog (PD6735) for treating sleep disorders and circadian rhythm disorders. Clinical studies suggest that PD6735 is safe, well tolerated and effective in reducing sleep latency in non-elderly adults with primary insomnia when used at doses up to 100 mg. A major FDA concern of all sleep medications is abuse potentia ...

DESCRIPTION (provided by applicant): More than 25 million people in the United States suffer from neuropathic pain. Currently available drugs include opioids, anti-epileptics, topicals such as lidocaine, NMDA antagonists, and tricyclic antidepressants, none of which achieve clinical significance greater than 50%. To address this problem of significant clinical need and poor clinical significance, ...

DESCRIPTION (provided by applicant): This Phase II proposal focuses on the development of accessible artificial intelligence (AI) software for individualized tutoring and formative assessment in chemistry education. If successful, an immediate outcome will be the very first AI tutoring systems for chemistry that are accessible to blind students, delivered through the Internet. An AI tutoring metho ...

DESCRIPTION (provided by applicant): One of the largest bottlenecks in high-throughput protein structure determination (structural genomics) and in subsequent drug targeting (pharmocogenomics) is the acquisition of soluble correctly folded functional protein products. Unfortunately, a large amount of the protein expression systems that are commonly used yield insoluble or soluble misfolded protein ...