Award Data

In Phase I, technical and commercial feasibility was demonstrated for the application of friction stir processing (FSP) following by superplastic forming (SPF) of a 5083 aluminum alloy, and for FSP following by room temperature bending. An application showing significant promise for FSP followed by SPF is an aluminum water tight door. The use of FSP followed by SPF enables a significant part co ...

DESCRIPTION (provided by applicant): To date no biological treatment options specifically targeting the proteolytic nature of chronic wounds have been developed and marketed. Chronic skin wounds constitute an important medical problem for the growing age d population. 18% of diabetic patients over the age of 65 suffer from chronic, non-healing foot ulcers, and it is estimated that over 50,000 lo ...

DESCRIPTION (provided by applicant): Studies of the molecular mechanisms underlying neoplastic transformation and progression have resulted in the understanding that cancer is a genetic disease, deriving from the accumulation of a series of acquired genet ic lesions. Despite advances in chemotherapy, radiation delivery, and surgical treatment regimens, survival from many advanced cancers remains ...

From anecdotal reports of the United State’s involvement in the Vietnam conflict, it was concluded that the kill rate for medics was substantially higher than that of regular infantrymen. Although to our knowledge quantifiable data do not exist, it seems likely that the situation is similar today for United States soldiers engaged in armed combat in Afghanistan and Iraq. Medics have historically ...

Emerging drug resistance in infectious threats poses a health risk for deployed forces. The primary objective of the Phase I effort was to enable the development of a sustainable drug discovery effort to continually generate lead compounds for discovery and derivative synthesis. Successful completion of Phase I demonstrated the utilization of a novel source of lead compounds, validation of two hi ...

DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tick vector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme d ...

DESCRIPTION (provided by applicant): In less than one year the 1918 Spanish flu pandemic claimed over 20 million lives worldwide, killing 675,000 Americans, more than 10 times the number of deaths to US servicemen in World War I. A similar strain of the vi rus that caused the 1918 pandemic could today kill 2 million Americans and force 10 million to be hospitalized. Although anti-viral drugs are k ...

DESCRIPTION (provided by applicant): The goal of this project is to develop a large-scale genotyping tool for metabolic muscle disease that can be applied to certain high risk groups in order to prevent life-threatening symptoms that are fast becoming a public health problem. The triggering of life-threatening metabolic muscle diseases by environmental factors such as drugs, viral infections, e ...

DESCRIPTION (provided by applicant): Abstract Patient-reported outcomes (PROs) are a component of health-related quality of life that measure aspects of a patient's health that come directly from the patient, typically via the use of valid and reliable que stionnaires. Methods of administration are traditionally paper forms or computerized/internet methods. Each of these current methods has signif ...

The objective of this proposal is to develop advanced radiation transport modeling techniques that accurately and efficiently treat transport in media having widely varying optical properties; in particular, hot gases and plasmas with optical depths ranging from the optically thin to the optically thick regimes. In doing this, we will develop a hybrid diffusion-Monte Carlo (HDMC) model that effic ...