Award Data

Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

DESCRIPTION (provided by applicant): Reliable diagnostic differentiation between acute and chronic myocardial infarcts would be of great benefit for cardiac surgeons and interventional cardiologists. Such differentiation could be used to make decisions about which vessels and in what order would be reopened or bypassed. MRI is an intrinsically noninvasive diagnostic tool and the Delayed Enhancemen ...

FreEnt Technologies, Inc. (FreEnt) and Johns Hopkins Universitys Applied Physics Laboratory (APL) are proposing a multiple-hit detection sensor called the Optical Lethality Measurement System (OLMS). This system is based on the Planar Optical Penetration Sensor (POPS) technology (originally developed and patented by APL) and prior art associated with the Blast Initiation Detector (BID). The BID is ...

The objective of this proposal is to further explore PbSnSe detector array on Si substrate. Two approaches are proposed. One is a zero-risk incremental advance that employs a new growth condition to reduce the dislocation density. Another approach is a novel fabrication technique with high-risk but it could enable revolutionary rather than evolutionary advances. IV-VI semiconductors such as Pb1-x ...

This effort proposes to design and demonstrate the concept of an innovative, Advanced BMDS Multisensor Fused Track and Discrimination Architecture that will enhance the generation of a Single Integrated Picture of the Battlespace. This Architecture permits enhancement of sensor-to-sensor track correlation handover of objects while characterizing their lethality for later target designation purpos ...

ABSTRACT: Missile defense radars use wideband waveforms along with coherent processing to extract detailed target features and perform high range /Doppler resolution functions. Reduced RCS targets embedded in high clutter (chaff, or chaff-like fuel debris, etc.) environments present significant challenges. Closely spaced objects and decoys accompanying targets of interest inherently increase the c ...

Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

The objective of this effort is to apply a systems-biology-centered methodology for the identification of subcellular mechanisms of mefloquine neurotoxicity, with the goal of developing a genetic profile to identify individuals predisposed to mefloquine neurotoxicity. The core hypothesis is that elucidating subcellular mechanisms of mefloquine neurotoxicity requires the combination of cellular lev ...

Subsequent Phase II Proposal, extension of Phase II contract N00039-12-C-0082. This contract involves the development of an underwater vehicle that can reliably and autonomously interconnect power and data cables to undersea nodes after they have been deployed. The Auto-Docking Autonomous Burial Vehicle (AD-ABV) is a cable-connecting adaptation of Makai’s proven ABV, which has been successfully ...

The overall objective of this project (Phase I, II, and III) is to develop, fabricate, and test a novel biofidelic rat surrogate for the validation of primary blast loading conditions for mild traumatic brain injury (mTBI). The CFDRC/NJIT team will use extensive knowledge of blast loading characteristics and TBI studies coupled with past/ongoing efforts designing and testing a rat surrogate. In P ...