Award Data

DESCRIPTION (provided by applicant): Elevated intracranial pressure (ICP) remains a critical problem in management of patients with neurological problems and is the most common cause of death in these patients. Elevated ICP can be managed and treated if detected at an early stage. Therefore, measurement of ICP is important for diagnosis and treatment decisions. At this time only invasive technique ...

Many Unites States Army, and other Department of Defense (DoD) sites, are contaminated with a variety of contaminants including highly energetic compounds, such as 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), chlorinated aliphatics (such as trichloroethylene,TCE) and chlorinated aromatics. These compounds often persist in soil or groundwater for extended periods of t ...

Many Unites States Army, and other Department of Defense (DoD) sites, are contaminated with a variety of contaminants including highly energetic compounds, such as 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), chlorinated aliphatics (such as trichloroethylene,TCE) and chlorinated aromatics. These compounds often persist in soil or groundwater for extended periods of t ...

The overall objective of the Phase II program is to develop a database of geopolymer-derived functional materials systems for ceramic matrix composities, including candidate materials for matrices and fiber-matrix interphase layers, which provide appropriate materials properties for performance in high temperature hydrothermal operating conditions at acceptable composite processing costs. Bot ...

DESCRIPTION (provided by applicant): The overall goal of this project is the development of a fully automated, wireless ethernet capable, near realtime, field deployable immunoassay-based analysis system for the concurrent, ultra low-level detection of biowarfare agents in air or water by using innovations in surface enhanced Raman scattering (SERS) and related supporting materials and hardware. A ...

DESCRIPTION (provided by applicant): Literacy holds a critical role in the lives of all children. Writing is an important part of literacy. It is crucial that students at risk for literacy learning difficulties, especially those with severe speech and physical impairments have access to exemplary literacy instruction that enables them to become successful readers and writers. The objective of this ...

DESCRIPTION (provided by applicant): Antibiotics are an essential component in bio-defense preparedness. Soil microorganisms were a major source of antibiotics during the 20th century, yet antibiotic discovery is now severely limited. A primary reason is that drug discovery from microorganisms has been confined to those microbes that can be recovered by laboratory cultivation, yielding high rates ...

DESCRIPTION (provided by applicant): Treatment of human immunodeficiency virus type 1 (HIV) infection with antiretroviral agents invariably leads to selection and accumulation of drug-resistant mutants that arise due to the intrinsically low fidelity of HIV polymerase. Early detection of these growing variants may be clinically relevant. Before the level of clinical importance can be ascertained, ...

DESCRIPTION (provided by applicant): This project will enhance the MASTERCATALOG, EraGen's product that combines an evolutionarily organized protein sequence database with tools to enable phylogenomics analysis. This will help maintain the commercial advantage of the MASTERCATALOG over public databases and tools, and help ensure that the MASTERCATALOG continues to enjoy its status as the "best in ...

DESCRIPTION (provided by applicant): Prostate cancer imaging with positron emission tomography (PET) has been facilitated by the recent development of the radioactive tracer fluorine-18 fluorocholine (F-18 FCH). Like other substrates for the enzyme choline kinase, F-18 FCH demonstrates increased accumulation in malignant cells. In addition to whole-body cancer staging, F-18 FCH PET may potentia ...