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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Restimulating memory T cell responses in elderly by a novel, live influenza vaccine

    SBC: Flugen, Inc.            Topic: NIAID

    Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwideImportantlyin humansthe majority of morbidity and mortality following flu infection is seen in older individualsrtyears oldYetclear understanding of how aging impacts on innate immune responsesand how to improve vaccine design in this age group is lackingRestimulating preexisting memor ...

    STTR Phase II 2017 Department of Health and Human Services
  2. Development of Environmental Health Education Games

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: NIEHS

    PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Mouse Stem Cell Research Using the Dracula Pipette

    SBC: GENESEARCH, INC.            Topic: 100

    Advanced approaches for genetic or epigenetic modification of embryonic stemEScellsincluding TALENZFNor CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAssynthetic mRNAsor recombinant transcription factorshave revolutionized our ability to modify the cells from which novel mouse lines are producedIn contrastprocedures for utilizing these cells within the context ...

    STTR Phase II 2017 Department of Health and Human Services
  4. A Novel Strategy to Identify Substances that Improve Mitochnodrial Fitness

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Highly sensitive isothermal method and instrument for field diagnostics to facilitate malaria eradication

    SBC: CASCADE BIOSYSTEMS, INC.            Topic: NIAID

    Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Graphene based Nanosensor Device for Rapid Onsite Detection of Dissolved Lead in Tap Water

    SBC: NANOAFFIX SCIENCE LLC            Topic: NIEHS

    PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Using Serious STEM Interactive Digital Technology To Understand Agriculture

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Range Encoded Difference Compression of EEG on a chip for Implantable Devices

    SBC: NEURALYNX INC            Topic: 101

    Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Field, clinic and lab preparation of emerging pathogens and other biological specimens for microscopy

    SBC: Microscopy Innovations, LLC            Topic: DHP16C004

    Biological tissues collection is problematic and risky even under ideal conditions: when collection occurs in remote locations, or by minimally-trained personnel, as may occur in response to an emerging disease threat, risks are magnified. This proposal addresses this issue by developing a Field Fixation Unit (FFU) for specimen collection that utilizes single-use capsules pre-loaded with fixative. ...

    STTR Phase I 2017 Department of DefenseDefense Health Program
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