Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Discovery of Anti-Bioweapon Agents in BAC Libraries

    SBC: EMETAGEN, LLC.            Topic: N/A

    DESCRIPTION (provided by applicant): Antibiotics are an essential component in bio-defense preparedness. Soil microorganisms were a major source of antibiotics during the 20th century, yet antibiotic discovery is now severely limited. A primary reason is that drug discovery from microorganisms has been confined to those microbes that can be recovered by laboratory cultivation, yielding high rates ...

    STTR Phase I 2004 Department of Health and Human Services
  2. Detecting Early Emerging Drug-Resistant HIV Populations

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of human immunodeficiency virus type 1 (HIV) infection with antiretroviral agents invariably leads to selection and accumulation of drug-resistant mutants that arise due to the intrinsically low fidelity of HIV polymerase. Early detection of these growing variants may be clinically relevant. Before the level of clinical importance can be ascertained, ...

    STTR Phase I 2004 Department of Health and Human Services
  3. Pharmacophylogenomic Dates for the Master Catalog

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This project will enhance the MASTERCATALOG, EraGen's product that combines an evolutionarily organized protein sequence database with tools to enable phylogenomics analysis. This will help maintain the commercial advantage of the MASTERCATALOG over public databases and tools, and help ensure that the MASTERCATALOG continues to enjoy its status as the "best in ...

    STTR Phase I 2004 Department of Health and Human Services
  4. Natural feedstocks for diversity oriented synthesis

    SBC: Promiliad Biopharma Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): This STTR application requests funds to support the transfer of specific synthetic expertise and methodologies from the Wright Group at Dartmouth College to investigators at Promiliad Biopharma in an effort to reduce Promiliad's REBACS strategy to the level of practice. These efforts will focus on the use of a high-complexity feedstock, nonactic acid, as the p ...

    STTR Phase I 2004 Department of Health and Human Services
  5. Endogenous Retrovirus Herv-K in Lymphoma and ALS

    SBC: SLIL BIOMEDICAL CORPORATION            Topic: N/A

    DESCRIPTION (provided by investigator): Retroviruses have long been associated with both hematological malignancies and neurological disorders in humans. Infection with the retrovirus HTLV-1 can lead either to the development of adult T cell leukemia (ATL) or HTLV-1 associated myelopathy. Infection with HIV is associated with the development of Non- Hodgkin's lymphoma (NHL) and the development of ...

    STTR Phase I 2004 Department of Health and Human Services
  6. Therapeutic Antimicrobial Human Skin Substitute

    SBC: Stratatech Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate goal of our proposal is to genetically engineer a therapeutic human skin substitute for use in the treatment of skin lesions such as skin wounds (e.g., pathological or traumatic) and ulcers (e.g., venous and diabetic ulcers). Chronic skin ulcers are particularly problematic as they typically become infected resulting in impaired wound healing an ...

    STTR Phase II 2004 Department of Health and Human Services
  7. Efficacy of Liposomal Budesonide in Experimental Asthma

    SBC: VGSK, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Asthma is the most common chronic illness in childhood and affects 5 to 10% of the population. The disease is characterized by acute bronchoconstriction, chronic inflammation, and airway remodeling which may lead to progressive, irreversible lung damage. Current asthma therapy is directed at reducing the lung inflammation with the use of anti-inflammatory drugs ...

    STTR Phase I 2004 Department of Health and Human Services
  8. Biofilm Restoration for Contaminated Army Sites

    SBC: CENTER FOR INNNOVATION, INC.            Topic: N/A

    Many Unites States Army, and other Department of Defense (DoD) sites, are contaminated with a variety of contaminants including highly energetic compounds, such as 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), chlorinated aliphatics (such as trichloroethylene,TCE) and chlorinated aromatics. These compounds often persist in soil or groundwater for extended periods of t ...

    STTR Phase I 2004 Department of DefenseArmy
  9. Biofilm Restoration for Contaminated Army Sites

    SBC: CENTER FOR INNNOVATION, INC.            Topic: ARMY03T13

    Many Unites States Army, and other Department of Defense (DoD) sites, are contaminated with a variety of contaminants including highly energetic compounds, such as 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), chlorinated aliphatics (such as trichloroethylene,TCE) and chlorinated aromatics. These compounds often persist in soil or groundwater for extended periods of t ...

    STTR Phase II 2004 Department of DefenseArmy
  10. Ruminant B-Lymphocyte Yellow Fluorescent Protein Aggregation Bioassay for Elk Chronic Wasting Disease

    SBC: Nomadics, Inc.            Topic: A04T027

    The goal of the proposed research is to develop a cell culture model for elk chronic wasting disease (CWD) prion propagation that can be used as a bioassay for detecting CWD. Our goal will be accomplished by bioengineering a bovine B-lymphocyte cell (B-cell) line to surface express elk PrPc fused to yellow fluorescent protein (YFP). Interaction of these B-cells with infectious, mis-folded, proteas ...

    STTR Phase I 2004 Department of DefenseArmy
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