Award Data

Traumatic brain injury is a common problem in both the military and civilian communities, but current treatment protocols are focused on managing symptoms and fail to prevent significant long-term repercussions. In the proposed program, Luna will demonstrate the feasibility of a liposome-based therapeutic delivery system capable of delivering hydrophilic and hydrophobic therapeutics to the traumat ...

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

The consequence of physical and mental degraded performance is of critical importance not only to the Department of Defense (DoD) missions and sports persons, but also to the general population as well. Sweat is an information abundant medium that contains biomarkers that show relation to human cognitive levels. However, obtaining days of continuous sampling of sweat from the same dermal spot has ...

We have identified NSI-566, a stable neural stem cell line, isolated and expanded from a single human fetal spinal cord tissue, as the investigational product for TBI treatment.NSI-566 has been approved by the US FDA as an investigational product for clinical testing in ALS (IND# 13905) and chronic SCI (IND# 14413) which are ongoing.For TBI treatment, we propose to place deposits of NSI-566 into t ...

Joint reduction is a key skill and is a core competency for orthopedic surgeons deploying as part of a trauma team.Current training options are limited to classroom instruction on uninjured persons due to lack of a suitable training simulator. The first true reduction performed by medical providers is on actual patients. This method of instruction prevents the trainee from developing the comfort a ...

The objective of this proposal is to demonstrate the feasibility of producing molded polyurethane viscoelastic foam ear seals with an integral skin, that we call Contoured Foam Pads (CFPs). These CFPs will have a surface profile that has targeted conformability around obstacles that results in an improved acoustic seal around eyeglasses from the military Approved Protective Eyewear List (APEL) and ...

Currently, deployed medics are required to transport, maintain and be resupplied with liquid-based medications and materials that are heavy, expensive to transport, perishable and may require refrigeration.Many medications and materials are or will be available in concentrated or dehydrated formularies that require sterile water for injection (SWFI) to rehydrate for immediate use, such as Lactated ...

Clinicians have recognized that the nature of diseases can be highly individual resulting in different patterns of onset and progression. In turn, the response of an individual to drugs is also unique and governed by a variety of factors. Pharmacokinetic models represent the movement of a drug through the body, and personalized pharmacokinetic models aim to capture the unique responses of specific ...

Medical simulation serves to bridge the gap between classroom presentation and live tissue training. Although simulation training can never completely replace live tissue training, it can enable earlier, more repetitive and more cost-effective training in proper technique, thereby accelerating development of the necessary cognitive and psychomotor skills. As combat medical training using human pat ...

Data protection/cybersecurity is an urgent concern touching all industries, governments, and private citizens. Attacks, ranging from an individual actor with self-serving purposes to state-sponsored campaigns, are experienced across modalities and by most every system. Efforts to thwart these attacks are focused both on maintaining data/system integrity (i.e. prevention of perversion or loss) and ...