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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. MEMS Lamellar Based Interferometer for the Detection of Toxic Chemicals

    SBC: AGILTRON, INC.            Topic: CBD10104

    Leveraging on Agiltron’s industry leading development of optical MEMS devices and the PI’s experience with FTIR spectrometer design, we propose to develop a new class of high performance compact and rugged FTIR spectrometers for LWIR optical range. The design is based on the MEMS lamellar mirror technique. Although this approach is not new, it has not yet been efficiently applied to LWIR, and ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  2. Low noise longwave infrared (8-12µm) focal plane array with high sensitivity for passive hyperspectral standoff detection

    SBC: APPLIED NANOFEMTO TECHNOLOGIES LLC            Topic: CBD10105

    Longwave infrared (LWIR, 8-12µm) focal plane arrays (FPAs) play an important role in hyperspectral chemical and biological sensing. Existing thermal detectors are unable to meet the high sensitivity and fast response requirements of many hyperspectral chemical and biological sensing applications. Photodetectors and FPAs based on photon excited electron generation process can fulfill the speed and ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  4. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  5. Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device

    SBC: Physical Optics Corporation            Topic: CBD10102

    To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses in-house developed mature compone ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  6. Miniature Residual Life Indicator

    SBC: Physical Optics Corporation            Topic: CBD10106

    Impregnated ASZM-TEDA carbon employed as highly adsorptive materials in Collective Protection (ColPro) systems loses the ability to adsorb toxic chemicals because of exposure to temperature, humidity, battlefield contaminants, and other pollutants. To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of probing the degradation in physical adsorption ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  7. 3D Microfluidic Platform for in vitro Hematopoietic Stem Cell (HSC) Culture

    SBC: Physical Optics Corporation            Topic: CBD10103

    To address the Chemical/Bio Defense (CBD) need for in vitro models suitable for high-throughput screening of drug toxicities in human tissues, Physical Optics Corporation (POC) proposes to develop a new three-dimensional (3D) Microfluidic Platform for in-vitro Hematopoietic Stem Cell (HSC) Culture (3D-Mic-Stem). This proposed system is based on a 3D microfluidic design that uses HSCs for assaying ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  8. Microfluidic Dielectrophoretic Screening System

    SBC: Physical Optics Corporation            Topic: CBD10107

    To address the U.S. Army/DTRA’s CBD program need for a robust screening process for use with large panels of enzymes to identify variants with higher affinity for organophosphorus (OP) substrates, Physical Optics Corporation (POC) proposes to develop a Microfluidic Dielectrophoretic Screening (MDS) system. This proposed system is based on the new design of a microfluidic mixer, enzymatic reactor ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  9. Next Generation Integrated Electrophoretic Nanofluidic Biochip Sensor Platform for the THz Spectroscopic Finger Printing of Biological Species and Age

    SBC: REDONDO OPTICS, INC.            Topic: CBD10110

    Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate an integrated electrophoretic nanofluidic biochip sensor platform for the accurate, reliable, and fast-throughput “label-less” THz spectroscopy finger printing of biolo ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  10. Enhancing the Pharmacokinetic Profile of Protein-based Drugs

    SBC: EXTEND BIOSCIENCES INC            Topic: CBD12101

    Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This would be of par ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
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