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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multiple Indication Adjuvants

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: CBD08105

    The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant pot ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  2. Dynamic Multicomponent Optical Analyzer for Chemical Weapon (CW) Exposure Studies

    SBC: SPECTRAL SCIENCES INC            Topic: CBD08104

    Spectral Sciences Inc. proposes to develop a prototype sensor for real-time trace-level analysis of complex multicomponent gas mixtures, specifically those containing Chemical Weapon (CW) agents and interferents. The instrument is based on high power quantum cascade lasers and photocoustic spectroscopy detection. Advanced detection algorithms take advantage of wide spectral coverage to provide hi ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  3. Collective Protection for Military Working Dogs

    SBC: TECHNICAL PRODUCTS INC            Topic: CBD08103

    Doctrine for employment of canines in a CBRN environment has evolved into a Collective Protection approach. Providing COLPRO has several very significant implications for Canine kennels and shelters: „X The outer surface of the structure must be CB agent impervious „X The outer surface of the structure must resist effects of the decontamination process „X The system must provide the animal ...

    SBIR Phase I 2008 Department of DefenseOffice for Chemical and Biological Defense
  4. MEMS Lamellar Based Interferometer for the Detection of Toxic Chemicals

    SBC: AGILTRON, INC.            Topic: CBD10104

    Leveraging on Agiltron’s industry leading development of optical MEMS devices and the PI’s experience with FTIR spectrometer design, we propose to develop a new class of high performance compact and rugged FTIR spectrometers for LWIR optical range. The design is based on the MEMS lamellar mirror technique. Although this approach is not new, it has not yet been efficiently applied to LWIR, and ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  5. Low noise longwave infrared (8-12µm) focal plane array with high sensitivity for passive hyperspectral standoff detection

    SBC: APPLIED NANOFEMTO TECHNOLOGIES LLC            Topic: CBD10105

    Longwave infrared (LWIR, 8-12µm) focal plane arrays (FPAs) play an important role in hyperspectral chemical and biological sensing. Existing thermal detectors are unable to meet the high sensitivity and fast response requirements of many hyperspectral chemical and biological sensing applications. Photodetectors and FPAs based on photon excited electron generation process can fulfill the speed and ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  6. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  7. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  8. Enhancing the Pharmacokinetic Profile of Protein-based Drugs

    SBC: EXTEND BIOSCIENCES INC            Topic: CBD12101

    Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This would be of par ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  9. An automated, high throughput, resin-free device for large scale protein purification

    SBC: CFD RESEARCH CORPORATION            Topic: CBD12102

    Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  10. High Capacity Supported Ionic Liquids for Carbon Dioxide Capture in Rebreather Systems

    SBC: BUSEK CO., INC.            Topic: CBD12106

    Busek Co. Inc. and Ionic Research Technologies, LLC propose to develop a novel carbon dioxide and water removal technology using ionic liquids for closed circuit self-contained breathing apparatus that will extend its operating lifetime, while simultaneously reducing overall weight and logistic burden. Ionic liquids offer unique characteristics including high capacity CO2 capture, tunable gas sel ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
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