Award Data

The Department of Defense (DoD) has a demand for out-of-production parts to maintain mission readiness of various weapons platforms. Additive manufacturing (AM) is an exciting and promising manufacturing technique that can make out-of-production parts and holds the potential to solve supply chain issues, such as high costs (i.e. for low-volume parts) and sole sourcing risks. The ability of AM to s ...

Additive Manufacturing (AM) is a modern and increasingly popular manufacturing process for metallic components, but suffers from well known problems of inconsistent quality of the finished product. Process monitoring and feedback control are therefore crucial research areas with a goal of solving this problem. To address this concern, X-wave Innovations, Inc. (XII) and the University of Dayton Res ...

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics) ...

Traumatic injuries account for 30% of all life years lost in the US and is the leading cause of death for people under 46 years of age. Uncontrolled bleeding or hemorrhage constitute 30-40% of trauma related deaths and are considered to be a major cause o

Traumatic brain injury (TBI) often occurs when a sudden trauma or head injury disrupts the function of the brain. Common causes of TBI include damage caused by explosive devices, falls and vehicle or motorcycle accidents. Sepsis is the result of a massive immune response to bacterial infection that gets into the blood. Sepsis often leads to organ failure or injury, and has always been a significan ...