Award Data

DESCRIPTION (provided by applicant): Project Summary This Phase I SBIR project is designed to develop new zwitterionic graft methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more active lives, total joint replacement is becoming more common. Current orthopedic joints have average lifespans of approximately 20 years. By that point wear on the joint causes p ...

TBD

Abstract In this Phase II SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the develo ...

DESCRIPTION (provided by applicant): Alcohol and drug (AOD) abuse by employees causes many costly problems for business and industry including absenteeism, injuries, health insurance claims, loss of productivity, employee morale, theft, and fatalities. The loss to companies in the United States totals 184.6 billion a year. There are 150 million Americans in the labor force, of whom 10.5 percent o ...

DESCRIPTION (provided by applicant): Workers aged 50 and older are at particular risk for a variety of diseases and disabling conditions that can erode their health and productivity and increase the costs of health care. Research has shown that worksite-based health risk appraisals and tailored, theory-based health promotion programs can provide cost- effective means to improve the health and prod ...

DESCRIPTION (provided by applicant): The aim of the project in Phase II is to develop and evaluate a stand-alone, Web-based serious game titled Vstreet-G, and to complete the interactive multimedia instruction on money management by adding a component on investment skills. Emancipation from dependence to living independently is one of the most challenging and feared life events for youth, especial ...

DESCRIPTION (provided by applicant): Squamous cell cancer of the head and neck (SCCHN) is locally invasive, and frequently spreads to the cervical lymph nodes. Locally advanced disease is treated with radiotherapy plus chemotherapy and/or cetuximab (an anti-EGF receptor antibody), but the cure rate is less than 40% and toxicities are severe. The overall goal of this SBIR grant proposal is to enhan ...

DESCRIPTION (provided by applicant): Nicotine addiction poses a serious public health problem in the United States. Cigarette smoking alone has been identified as the cause of numerous diseases, including cancers (e.g., lung, bladder, kidney, and oral cancers, among others), cardiovascular diseases (e.g., atherosclerosis and coronary heart disease, among others), and respiratory diseases (e.g., pn ...

DESCRIPTION (provided by applicant): The application's broad, long-term objectives are to develop a rapid, high-throughput clinical assay for 3' fibrinogen that will be used to assess the risk of a patient developing venous thromboembolism. This assay will guide clinical management, particularly the use of long-term anticoagulant therapy for patients. The utility of this assay will be the identifi ...

PROJECT SUMMARY Thoracic aortic aneurysmTAAis a chronic condition that carries the risk of developing life threatening complications such as aortic dissectioni edelamination of the aortic walland rupturei etransmural tearingThe primary management objectives for TAA are to identify aortic dilation early and to surgically replace the aorta before it reaches a size that predicts future complicationsI ...