Award Data

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies. Although TE cartilage presently lacks the mechanical stability of native cartilage, studies have demonstrated that mechanical stability can be e ...

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

Aurora Flight Sciences and MIT propose to develop a model-based adaptive health estimation and real-time proactive control to identify gas turbine engine stability risks and avoid them through control action. In this concept, the engine control system actively monitors sensors and actuators, compares them against physical models, and infers which components may be performing poorly and may need to ...

DESCRIPTION (provided by applicant): A high percentage of the ~ 500,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition (TPN) solution, which is prepared from component solutions: small and large volume parenterals (SVPs and LVPs). Aluminum (Al) is a common contam ...

DESCRIPTION provided by applicant We devised a new generation highly sensitivity method to diagnosis peripheral neuropathy early when the probability for reversal is greatest Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA Both cause decreased sweating abnormal circulation peripheral numbness pain and weakness If diagnosed early both are potentially ...

Northwest UAV Propulsion Systems proposes using our purpose built heavy fuel engine designed and built in the USA for small unmanned aerial systems in the tier 2 & 3 class. We will be adding a lightweight ceramic material set combined with FEA (Finite Element Analysis) and heavy fuel atomizer (IRAD Project) to create a lightweight engine for a SUAS or STUAS class UAVs. The Ceramic material set is ...

Advances in electronically controlled injection technologies for diesel engines have provided a method to improve medium- to heavy-duty engine performance through increased injection pressures, multiple injections, and injection rate shaping. Although these injection systems have been primarily limited to larger engines, the ability to rapidly and precisely meter fuel for smaller engines is partic ...

The requirements for thermal management on tactical aircraft systems have reached a level at which integrated system design must be considered early in the aircraft design process. An integrated propulsion, power and thermal modeling and simulation design approach is necessary for reduced size, weight and power requirements. At the same time, there is an urgent need for capabilities that enable an ...

DESCRIPTION (provided by applicant): Becoming a mother is a significant transition in a woman's life. This transition can precipitate major changes in health behaviors, like physical activity. Once a woman has a child she is much less likely to participate in regular, moderate to vigorous physical activity compared to women without children. Thus, new mothers are at risk for future weight gain and ...

PROJECT SUMMARY Genomic instabilityinduced by DNA damageand partly mitigated by DNA repair and antioxidantsplays a critical role in the pathogenesis of many major human diseasessuch as neurodegenerationcancer and cardiovascular diseasetogether with agingThere is a critical need for automated assays that can perform these assessmentsand bring them into greater routine usewhich will help advance our ...