Award Data

DESCRIPTION (provided by applicant): Improvements in the safety and efficacy of warfarin therapy will result from intelligent application of knowledge derived from inherited characteristics (CYP2C9 and VKORC1) of individual patients, only when this knowledge is applied through a standardized interventional approach. The fundamental pharmacologic influences of CYP2C9 and VKORC1 have been unequi ...

The U.S. military’s next-generation radio system, JTRS, is based on Software Defined Radio (SDR) technology and will create new opportunities, methods, and applications for generating and sharing tactical data. One of the many challenges in realizing the JTRS vision is to create small, lightweight, embeddable devices that operate from battery power, meet the requirements for performance, SCA com ...

DESCRIPTION (provided by applicant): The rat is a favored model for many types of human disease for which mice are not suitable. As opposed to the mouse, rats and humans also share more similarity in their cytochrome P450 genes, making the rat a more useful model for toxicology and pharmacology studies. The rat is also a favored model for diabetes, arthritis, behavioral disorders (including drug a ...

DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be diagnosed with GBM this year, most will succumb within the first year. Clearly, there is an urgent ...

The availability of fresh potable water is restricted in many environments. This could be corrected by the distillation of sea water; however the cost is very high due in large part to the requirement for titanium heat exchangers to provide the required corrosion resistance. A new low cost process combined with very low cost raw materials is being developed to provide a substantial reduction in th ...

A versatile and portable instrument for stray light detection and diagnosis at both visible and infrared wavelengths will be designed, built, and demonstrated. The core idea of the proposed approach is to use subaperture, rather than full aperture, illumination for stray light detection. The subaperture approach uses a scanning pencil beam (SPB) that provides information about the location of a s ...

The state-of-the-art FPA manufacturing technologies commonly generate some critical defects in the pixel elements, which adversely impact their operability and reliability. In Phase I, the feasibility of identifying, analyzing, and on exemplary basis, eliminating these defects indirectly through nanostructural analysis was demonstrated. In Phase II, this defect analysis and correlation approach ...

DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

DESCRIPTION (provided by applicant): The goal of this project is to develop an automated respiratory rate monitor that is economical, easy to use, accurate and widely accessible. The motivation for this project is well documented findings that respiratory rates are not accurately measured in many medical settings, such as, emergency rooms and general hospital wards. The respiratory rate is a core ...

DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stages when therapeutic interventions would likely have the greatest efficacy. The basic hypothesis of this project is that levels of a unique high mo ...