Award Data

Technical AbstractAs with many chemotherapeutic drugstaxanes exhibit poor oral bioavailabilityhencethey are administered intravenouslyi vThis regimen results in significant toxicitiesdue to both the high drug dose and vehicleCremophore ELRusedAttempts made to develop an oral chemotherapeuticusing liposomes and polymeric nanoparticles as carriershave not made it to the clinicdue to their inherent l ...

ABSTRACT Simple protein mutations can have serious consequences by causing diseases that affect peopleandapos s lives Protein therapeutics are developed to target and replace those protein mutations and essentially to heal the disease Distinctively membrane proteins make up over of todayandapos s drug targets However cumbersome time consuming and often ineffectual purification methods ...

Navy needs a real-time graph embedding tool for analyzing huge graphs (millions of nodes and billions of edges) from diverse sources. However, current approaches cannot provide dynamic and scalable graph analytics to signify the military value of tactical data. In this project, InfoBeyond advocates EStreaming (Embedding & Streaming) for scalable and efficient graph streaming. EStreaming promotes b ...

The broader impact/commercial potential of this project consists of providing a new means for visually impaired people to understand information via haptics. In order to accomplish this, the company is creating micro actuators and refreshing displays that will permit the blind to understand visual information quickly. One major potential societal benefit will be directly related to visually impair ...

Project Summary Abstract PowerTech Water PTW intends to demonstrate the use of inverted capacitive deionzation i CDI technology to target the removal of heavy metals lead Pb in particular from drinking water Heavy metals such as lead and copper can enter the water distribution system due to corrosion of pipes and fittings contaminating drinking water The US Environmental Protection Agen ...

Project Summary In eukaryotic cells ultra violet radiation UVR induces the formation of free radicals which damage cellular lipids proteins and nucleic acids In man this damage can lead to chronic inflammation and skin neoplasias so that compounds which protect cells from UVR are of therapeutic interest Flavonoids are candidates because they protect plant cells by absorbing UVR and acting ...

Advanced manufacture requires low-latency and high-reliability wireless communications between the sensors/actuators and the central controller. However, the current wireless protocols cannot meet such stringent latency and reliability requirements. In this project, InfoBeyond advocates L2Wireless (Low-Latency High-reliability Wireless Protocol Using Cooperative Relaying and Network Coding) to add ...

This SBIR project proposes the development of advanced catalyst technology for ultra-deep hydrodesulfurization and cetane number improvement process for diesel fuel. In Phase I of this project, Advanced Energy Materials, LLC. (AdEM) utilized its core technology of metal oxide nanowires platform for catalyst design, and successfully demonstrated the high performance of the two proposed catalysts: ( ...

Project Abstract PGXL Technologies is developing novel urine based tests for detecting obstructive sleep apnea OSA in children Obstructive sleep apnea OSA is a disorder giving rise to behavioral and learning problems including misdiagnoses as attention deficit hyperactivity disorder ADHD in children The CDC estimates the prevalence of pediatric OSA in the US at around million An ...

Abstract Alcohol dependence affects at leastof the US populationwith a financial cost in excess of $BnPrevention of relapse in patients attempting to reduce alcohol consumption is a major therapeutic targetbut current treatments are ineffectiveand there is an urgent need for new medicationsMajor factors in causing relapse include the protracted symptoms of withdrawal from alcoholwhich are relieved ...