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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. X-Ray Detectors for Synchrotron-Based Structural Biology

    SBC: AREA DETECTOR SYSTEMS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Development is proposed of an x-ray Pixel Array Detector (PAD) consisting approximately of 2,000 x 2,000 pixels to enhance macromolecular crystallographic data collection at synchrotron sources. A PAD consists of an x-ray sensing integrated circuit layer bonded to a pixel electronics layer such that each pixel has its own processing electronics. PADs promise t ...

    SBIR Phase II 2003 Department of Health and Human Services
  2. A Tunable, Tabletop, Synchrotron Light Source

    SBC: LYNCEAN TECHNOLOGIES, INC.            Topic: N/A

    N/A

    SBIR Phase II 2003 Department of Health and Human Services
  3. Prophylactic Anthrax Toxin Vaccine

    SBC: VICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Vical Inc. seeks SBIR Phase II funding to develop and produce a licensable prophylactic anthrax vaccine. This project will move on an accelerated but realistic timeline with plans for human clinical trials to begin in September 2003. Although many candidate vaccines are being studied for anthrax prevention or post-exposure prophylaxis, the Vical approach has ...

    STTR Phase II 2003 Department of Health and Human Services
  4. ALLOGENEIC TGF-B ANTISENSE CELL VACCINE FOR LUNG CANCER

    SBC: NOVARX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this study is to conduct a Phase II clinical trial in patients with incurable non-small cell lung cancer (NSCLC). Our aim is to induce antitumor immune responses by immunizing patients with an experimental vaccine comprised of four allogeneic NSCLC cell lines genetically modified with a TGFbeta 2 antisense vector. By blocking secretion of the imm ...

    SBIR Phase II 2003 Department of Health and Human Services
  5. Small Shuttle-Compatible Propulsion Module

    SBC: SPACEDEV            Topic: N/A

    The development of an orbital Maneuvering and Transfer Vehicle (MTV) that can be safely manifested aboard the Space Shuttle and meet U.S. Air Force Space Test Program orbit transfer performance requirements is critical to launching secondary experimentalpayloads from Space Shuttle Hitchhiker Experiment Launch System (SHELS). The objective of this project is to develop a prototype MTV Propulsion M ...

    SBIR Phase II 2003 Department of DefenseAir Force
  6. NOVEL ASSAYS FOR MEASURING THE INHIBITION OF VIRUS ENTRY

    SBC: MONOGRAM BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of HIV-1 infected patients with combinations of inhibitors of the viral protease (PR) and reverse transcriptase (RT) enzymes has been remarkably successful in suppressing viral replication and prolonging patient survival. However, extended administration of these antiretroviral (ARV) agents is commonly associated with the emergence of resistant vir ...

    SBIR Phase II 2003 Department of Health and Human Services
  7. Drug Development of a Chronic Pain Therapeutic

    SBC: ADVANCED TARGETING SYSTEMS            Topic: N/A

    DESCRIPTION (provided by applicant): SP-SAP, a conjugate between the peptide neurotransmitter substance P, and the ribosome-inactivating protein, saporin, has been shown, through previous NIH funding, to ablate chronic pain transmission in several rat models. Importantly, acute, reflexive pain perception remains intact. The conjugate acts by elimination of the small number of substance P receptor- ...

    SBIR Phase II 2003 Department of Health and Human Services
  8. Liver-Targeted Prodrugs for the Treatment of Hepatitis C

    SBC: METABASIS THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by investigator): The long-term objective of this application is to identify a potent, efficacious and safe drug for the treatment of hepatitis C virus (HCV) through the use of our proprietary HepDirect prodrug technology. It is estimated that >170 million people are infected with Hepatitis C virus worldwide. Despite recent improvements in HCV drug formulations, a large segm ...

    SBIR Phase II 2003 Department of Health and Human Services
  9. Complementary Adenoviral Vectors for Treatment of Cancer

    SBC: MAGNUM THERAPEUTICS            Topic: N/A

    DESCRIPTION (provided by applicant) The major goal of this proposal is to determine the therapeutic potential of a replication conditional adenovirus vector, DuaI-AdlL-3. This vector system is composed of two transcomplementing adenoviruses that permit selective replication in the prostate and prostate tumors. It is designed to engender a multimodal therapeutic response by establishing a lytic i ...

    SBIR Phase II 2003 Department of Health and Human Services
  10. Web Based Phenotyping With Magnetic Resonance Histology

    SBC: MRPATH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In phase I of the project we have demonstrated the feasibility of web based morphologic phenotyping of the mouse using magnetic resonance histology. We have exceeded our goal of isotropic resolution at 100 microns by 8x with isotropic resolution at 50 microns. While this spatial resolution provides extraordinary anatomic detail, it results in enormous volume ...

    SBIR Phase II 2003 Department of Health and Human Services

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