Award Data

Diode-laser arrays operating in the visible region of the spectrum offer advantages for illuminator applications, particularly for night and water penetration capability. Recent developments in diode-laser materials allow operation throughout the visiblespectrum. At this time, red diode-laser technology is more mature than the existing blue-green or violet diode-laser technology. The novel aspe ...

DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...

DESCRIPTION (Unedited Applicant's Abstract):When people with diabetes reach end-stage renal disease they must undergo either dialysis or transplantation. About 200,000 Americans need artificial kidney machines to stay alive. These machines rely on sterile dialysis membranes to remove toxic materials from the bloodstream. More than 30 different polymers or polymer blen ...

DESCRIPTION (Verbatim from the Applicant's Abstract): This Phase I SBIR application seeks support to develop and evaluate a naturally-occurring extracellular matrix (ECM) bioscaffold material for tissue engineering applications; specifically, the repair and/or restoration of congenital defects in which lost or missing tissue is the limiting factor for s ...

NON-TECHNICAL SUMMARY: The sugar industry produces over 100 million tons of sugar each year. This large industry has been intrigued by the use of membranes to enhance the efficiency of production for many decades but membranes that have the correct combination of performance and cost have not yet been developed for consideration in large scale installations. High temperature, high viscosity, and m ...

DESCRIPTION: (provided by applicant) The goal of this program is to develop accelerator mass spectrometry (AMS) as an analytical tool for cancer research, specifically for tracing the interactions of carcinogens and cancer chemotherapeutic drugs with their biomolecular targets. AMS is a highly selective means for d ...

Use of a new noninvasive test for the accurate early detection of preeclampsia is proposed as a tool to screen women during early stages of pregnancy. Preeclampsia affects 10% of the 4 million pregnancies in the U.S. each year and is the leading cause of maternal and neonatal medical complications and death. There is currently no means of detecting preeclampsia prior to onset of clinical symptoms ...

DESCRIPTION (provided by applicant): Increased stiffness of large central conduit vessels has recently emerged as an important risk factor for cardiovascular disease. Abnormalities in conduit vessel stiffness are highly prevalent and are associated with several important clinical conditions including hypertension, diabetes, menopause, and advancing age. Increased conduit vessel stiffness increases ...

Chemotherapeutic dosing has traditionally been empiric, with all patients receiving the same dose adjusted for body surface area (BSA). Unfortunately, while this may be adequate for the average person, it can be inappropriate for the majority of patients. Pharmacokinetic and pharmacodynamic factors are key components contributing to drug toxicities. Variations in metabolic enzyme activity have bee ...

We will develop a vapor phase detector of the chemicals/explosives associated with nuclear weaponry. Radioactivity detection allows accurate weapons verification, but provides too much information on the weaponry design. An alternative is to detect otherchemicals associated with nuclear weaponry. EIC Laboratories has successfully developed vapor phase Surface Enhanced Raman Spectroscopy (SERS) ...