Award Data

DESCRIPTION (provided by applicant): In phase I of the project we have demonstrated the feasibility of web based morphologic phenotyping of the mouse using magnetic resonance histology. We have exceeded our goal of isotropic resolution at 100 microns by 8x with isotropic resolution at 50 microns. While this spatial resolution provides extraordinary anatomic detail, it results in enormous volume ...

DESCRIPTION (provided by applicant): Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27.3 billion in direct diabetes in-patient medical expenses is used for the treatment of foot ulcers. There is clearly a si ...

DESCRIPTION (provided by applicant): This SBIR fast-track application proposes to develop, evaluate, and implement an Internet-based system, called HealthProposal.net to enable electronic grant application preparation and submission. In response to NIH RFA-RR-02-004 (ERA-SBIR) we seek to: 1) provide a state-of-the art web-based interface that enables electronic grant submission, 2) utilize open so ...

N/A

DESCRIPTION (provided by applicant): The goal of this research project is to develop a new technology for microarray analysis that has superior performance and is more affordable than the currently available fluorescence-based microarrays. In Phase-I we have provided proof-of-principle for the proposed approach of reading a DNA microarray produced directly on the surface of a computer diskette. Wi ...

DESCRIPTION (provided by investigator): Research-based drug abuse prevention programs are now widely disseminated; however, adopting and implementing a research-based program does not, by itself, guarantee that desired outcomes will be achieved. Research on fidelity of implementation reveals that teachers are not sufficiently well trained in drug abuse prevention theory and practice. As a consequ ...

DESCRIPTION (provided by applicant): The aim of the research project is to develop a very inexpensive and rapid capacitance measurement technique that can be used as a diagnostic test to identify specific infectious organisms, their resistance to antimicrobial drugs, and their pathogenicity in a clinical setting. The goal is to make the cost so low that managed health organizations would encourage ...

DESCRIPTION (provided by applicant): The aim of the research project is to further develop the dual hybridization diagnostic genotyping method into a multiplex assay capable of using unlabeled, unamplified DNA as the target. The feasibility of the dual hybridization method was demonstrated in Phase I using amplified targets and single fluorophore labels. All results indicate that the method will t ...

DESCRIPTION (provided by applicant): Atmospheric Glow Technologies proposes a novel method of cold sterilization and biofilm destruction of medical and dental materials. The effort will use the One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) technology to attack and destroy biofilms, which cause serious problems on medical and dental instruments and devices. The use of atmospheric plasma to ...

DESCRIPTION (provided by applicant): Galactosemia is a potentially lethal, but preventable, disease of newborns. In Phase I of this grant, we demonstrated that a 13C-galactose breath test could be used to assess the degree of impairment of whole body galactose oxidation in more than 90 galactosemic children with a broad spectrum of mutations in the human GALT gene that codes for galactose-l-phosph ...