Award Data

DESCRIPTION (provided by applicant): In phase I of the project we have demonstrated the feasibility of web based morphologic phenotyping of the mouse using magnetic resonance histology. We have exceeded our goal of isotropic resolution at 100 microns by 8x with isotropic resolution at 50 microns. While this spatial resolution provides extraordinary anatomic detail, it results in enormous volume ...

DESCRIPTION (provided by applicant): Progression of diabetic foot ulcers is the leading cause of lower limb amputations in the U.S. More than 800,000 foot ulcers are treated annually with progression to more than 86,000 amputations each year. Between 1/4 to 1/2 of the $ 27.3 billion in direct diabetes in-patient medical expenses is used for the treatment of foot ulcers. There is clearly a si ...

DESCRIPTION (provided by applicant): This SBIR fast-track application proposes to develop, evaluate, and implement an Internet-based system, called HealthProposal.net to enable electronic grant application preparation and submission. In response to NIH RFA-RR-02-004 (ERA-SBIR) we seek to: 1) provide a state-of-the art web-based interface that enables electronic grant submission, 2) utilize open so ...

Accurate Automation Corporation (AAC) has developed a new artificial neural network processor (NNP) based upon a sparse Multiple Instruction Multiple Data (MIMD) structure which is ideally suited for Electronic Warfare (EW) applications. The proposed research will investigate the use of the AAC NNP for EW applications such as emitter identification which is used in ELINT, ESM, and RWR receivers. T ...

DESCRIPTION (provided by applicant): The goal of this research project is to develop a new technology for microarray analysis that has superior performance and is more affordable than the currently available fluorescence-based microarrays. In Phase-I we have provided proof-of-principle for the proposed approach of reading a DNA microarray produced directly on the surface of a computer diskette. Wi ...

DESCRIPTION (provided by investigator): Research-based drug abuse prevention programs are now widely disseminated; however, adopting and implementing a research-based program does not, by itself, guarantee that desired outcomes will be achieved. Research on fidelity of implementation reveals that teachers are not sufficiently well trained in drug abuse prevention theory and practice. As a consequ ...

The feasibility of fabricating hypersonic aircraft components from metastable Beta Titanium alloy (Beta 21S) will be investigated. Techniques for the fabrication of the leading edges, inlet, and nozzle areas of a hypersonic (Mach 4-5) testbed aircraft from Beta 21S will be selected and preliminary drawings, specifications, and test procedures for these components will be developed.

This Phase I program would examine the feasibility of developing aircraft seat cushions that can help crews of the AH-1W to survive crashes. The effort will focus on adapting novel hydraulic air cushioning structures (HACS) to absorb the impact energy of a crash. These HACS structures, which are elastomeric compounds with controlled air-flow passages, when incorporated within the seat or cushion, ...

DESCRIPTION (provided by applicant): The aim of the research project is to develop a very inexpensive and rapid capacitance measurement technique that can be used as a diagnostic test to identify specific infectious organisms, their resistance to antimicrobial drugs, and their pathogenicity in a clinical setting. The goal is to make the cost so low that managed health organizations would encourage ...

DESCRIPTION (provided by applicant): The aim of the research project is to further develop the dual hybridization diagnostic genotyping method into a multiplex assay capable of using unlabeled, unamplified DNA as the target. The feasibility of the dual hybridization method was demonstrated in Phase I using amplified targets and single fluorophore labels. All results indicate that the method will t ...