Award Data

DESCRIPTION provided by applicant APDM is a young company focused on developing and commercializing professional systems using wearable inertial sensors for monitoring of human movement and movement disorders In Phase I we developed the novel Instrumented Stand and Walk test ISAW using APDMandapos s proprietary Opal movement monitors and Mobility Lab system We validated the ISAW by demon ...

DESCRIPTION provided by applicant The worldwide health problem created by malaria has been made more difficult by the spread of drug resistant parasites We have developed an orally available and inexpensive class of novel drugs that act against both chloroquine resistant and chloroquine sensitive malaria This project carries on preclinical development of a drug candidate that has been select ...

DESCRIPTION provided by applicant Corneal clouding caused by failure of the corneal endothelial deturgesence mechanism affects over million people in the US and well over million people worldwide It is the most common corneal disease and is historically a common cause of blindness Surgical treatment by corneal grafting has been successful when available but is limited by the availabili ...

DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

DESCRIPTION provided by applicant Perioperative hemorrhage remains the major complication of transurethral and open prostatic surgical procedures Significant blood loss from these procedures causes delayed healing and longer hospitalization which significantly increases the cost of patient care Moreover prolonged urethral catheterization due to significant post operative hematuria is one of ...

DESCRIPTION provided by applicant Traumatic brain injury TBI is an acquired neurological disorder that can cause long lasting disability with limited treatment options Therefore preventative strategies must be emphasized in high risk activities to reduce the individual and societal burden of this pervasive injury Bicycle activities account for of all sports related TBI with ...

This Phase II STTR program seeks a new fabrication method to produce stronger (>100 kpsi) and tougher (>10 MPam1/2) ultra-high temperature HfC-based composites (UHTC) with an outstanding oxidation resistance for advanced rocket nozzle throat components. UES will apply a novel"Top Down"approach to control the microstructures of the composites. This approach will produce a very unique grain structur ...

In this Phase II STTR project, RNET and its subcontractors are proposing to fully develop an empirical performance optimization tool called OrFPGA that efficiently explores the "user tunable" parameter space of an FPGA design and assists in deducing the near optimal design in terms of timing score, device utilization, and power consumption. The tunable parameter space will include IPCore parameter ...

The liberation of particles induced by rocket plume flow from spacecraft landing on unprepared regolith of the Moon, Mars, and other destinations poses high mission risks for robotic and human exploration activities. This process occurs in a combination of "extreme environments" that combine low gravity, little or no atmosphere, rocket exhaust gas flow that is supersonic and partially rarefied, an ...

Launch vehicles experience extreme acoustic loads during liftoff driven by the interaction of rocket plumes and plume-generated acoustic waves with ground structures. Currently employed predictive capabilities are too dissipative to accurately resolve the propagation of waves throughout the launch environment. Higher fidelity non-dissipative analysis tools are critically needed to design mitigatio ...