Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. IRE1 alpha inhibitors for type 2 diabetes

    SBC: Optikira, LLC            Topic: 200

    DESCRIPTION provided by applicant The American Diabetes Association has declared type diabetes T D a public health crisis T D begins as a state of compensated insulin resistance frank disease develops when of insulin producing pancreatic islet cells of affected individuals undergo cell death Endoplasmic reticulum ER stress has emerged as a central underlying mechanism that drive ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. STTR Phase I: Mechanical Surface Treatment for High Performance Biodegradable Implants

    SBC: SURFACE INTEGRITY, LLC            Topic: BM

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to shift current practices in bone fracture fixation care from using permanent metal implants to biodegradable metal implants (screws, plates, pins, rods, etc.). A promising biodegradable metal that is gaining widespread attention is magnesium. This project will advance magnesium implant te ...

    STTR Phase I 2015 National Science Foundation
  3. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Serious STEM Games To Educate Middle School Students

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: OD

    DESCRIPTION provided by applicant Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Real-time myoglobin saturation measurement to assess benefit of RBC transfusion

    SBC: Opticyte, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Critically ill patients commonly arrive at an intensive care unit with anemia While blood transfusions are the standard of care with the intention to increase or maintain oxygen delivery to tissues questions have been raised about the benefit of blood transfusions particularly in non bleeding patients with moderate anemia A noninvasive measure of intracellu ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. STTR Phase I: Advanced Manufacturing Processes for Multiple Field Freeform Microlens Arrays for Ultra-Low Cost Medical Endoscopy

    SBC: Ohio Surgical Optics, LLC            Topic: MN

    The broader impact/commercial potential of this Small Business Technology Transfer Research (STTR) Phase I project is that smaller and less expensive medical endoscopes will be made possible, which will allow physicians to see better inside the human body. These devices will shorten recovery times, improve diagnosis and treatment, move procedures from operating rooms to exam rooms, and lower healt ...

    STTR Phase I 2015 National Science Foundation
  7. STTR Phase I: New dwarfing genes to improve yield and abiotic stress tolerance in wheat

    SBC: Gene shifters, LLC            Topic: BT

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is the improvement of wheat yields by introducing newly identified dwarfing genes. The currently used dwarfing genes, which were instrumental in bringing about the "green revolution", are at least partly responsible for this bottleneck. These dwarfing genes, present in more than 90% of the wheat varie ...

    STTR Phase I 2015 National Science Foundation
  8. Ultra-Sensitive Diagnosis of AIDS-Related Tuberculosis

    SBC: AttoDx, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant This grant will develop a novel strategy to enhance the analytical sensitivity of polymerase chain reaction PCR based detection of bacteria in samples We will commercialize the strategy in the form of a pre PCR andquot turbo chargerandquot to be marketed in conjunction with PCR based molecular diagnostic systems The current STTR project will apply this str ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Mouse Stem Cell Research Using the Dracula Pipette

    SBC: GENESEARCH, INC.            Topic: 100

    DESCRIPTION provided by applicant Advanced approaches for genetic or epigenetic modification of embryonic stem ES cells including TALEN ZFN or CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAs synthetic mRNAs or recombinant transcription factors have revolutionized our ability to modify the cells from which novel mouse lines are produced In contra ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Novel Membrane Protein Solubilization/Stabilization Screen

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: 100

    DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government