Award Data

Guild Associates, Inc. proposes to develop and evaluate an active electrochemical sensor based residual life indicator (RLI) for adsorptive carbon filters. The sensing system of the RLI will operate by analyzing the electrochemical state of the carbon within the filter and evaluate the remaining adsorptive reactive capacities of the filter. The sensor design will be challenged against an array of ...

Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

Servicemembers exposed to blasts have frequent complaints of vertigo, gaze instability, balance problems, motion intolerance, and other symptoms consistent with peripheral vestibular pathology. Current vestibular rehabilitation is an exercise-based approa

Most standard-of-care tools and techniques for evaluating neck disorders are subjective, unreliable, and do not provide actionable information for providers, payers, and organizations to deliver efficient and effective care. This lack of objective neck he

For this SBIR Intelligent Automation Inc. (IAI), teamed with researchers from Department of Dermatology, University of Maryland School of Medicine, propose to develop a smartphone based dermatology diagnosis system, MDerm that can be operated by warriors

The goal of medical simulation-based training such as high-fidelity manikin simulators, part task trainers, and screen-based virtual patients, is to approximate real-life treatment experiences without risk to live patients. While the use of sensors has ma

Care for the wounded Warfighters in austere and remote settings makes medical knowledge, skills and efficiency of the military medical professional paramount. For wounds that extend deep into internal anatomy, proper visualization of internal anatomy can